دورية أكاديمية
The Roles of DNA Demethylases in Triple-Negative Breast Cancer
| العنوان: | The Roles of DNA Demethylases in Triple-Negative Breast Cancer |
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| المؤلفون: | Shoghag Panjarian, Jean-Pierre J. Issa |
| المصدر: | Pharmaceuticals, Vol 14, Iss 7, p 628 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | TNBC, TET enzyme, DNA methylation, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Triple-negative breast cancers (TNBCs) are very heterogenous, molecularly diverse, and are characterized by a high propensity to relapse or metastasize. Clinically, TNBC remains a diagnosis of exclusion by the lack of hormone receptors (Estrogen Receptor (ER) and Progesterone Receptor (PR)) as well as the absence of overexpression and/or amplification of HER2. DNA methylation plays an important role in breast cancer carcinogenesis and TNBCs have a distinct DNA methylation profile characterized by marked hypomethylation and lower gains of methylations compared to all other subtypes. DNA methylation is regulated by the balance of DNA methylases (DNMTs) and DNA demethylases (TETs). Here, we review the roles of TETs as context-dependent tumor-suppressor genes and/or oncogenes in solid tumors, and we discuss the current understandings of the oncogenic role of TET1 and its therapeutic implications in TNBCs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| العلاقة: | https://www.mdpi.com/1424-8247/14/7/628Test; https://doaj.org/toc/1424-8247Test |
| DOI: | 10.3390/ph14070628 |
| الوصول الحر: | https://doaj.org/article/3261eacc8e274c5e9b8e7e0f6ffbf7bbTest |
| رقم الانضمام: | edsdoj.3261eacc8e274c5e9b8e7e0f6ffbf7bb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph14070628 |