دورية أكاديمية
Extra-Gonadal and Non-Canonical Effects of FSH in Males
| العنوان: | Extra-Gonadal and Non-Canonical Effects of FSH in Males |
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| المؤلفون: | Matteo Spaziani, Francesco Carlomagno, Marta Tenuta, Franz Sesti, Francesco Angelini, Ilaria Bonaventura, Davide Ferrari, Chiara Tarantino, Marco Fiore, Carla Petrella, Luigi Tarani, Daniele Gianfrilli, Carlotta Pozza |
| المصدر: | Pharmaceuticals, Vol 16, Iss 6, p 813 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | FSH, extra-gonadal, bone, cardiovascular system, immune system, metabolism, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Recombinant follicle-stimulating hormone (FSH) is commonly used for the treatment of female infertility and is increasingly being used in males as well, as recommended by notable guidelines. FSH is composed of an α subunit, shared with other hormones, and a β subunit, which confers specificity of biological action by interacting with its surface receptor (FSHR), predominantly located in granulosa and Sertoli cells. However, FSHRs also exist in extra-gonadal tissues, indicating potential effects beyond male fertility. Emerging evidence suggests that FSH may have extra-gonadal effects, including on bone metabolism, where it appears to stimulate bone resorption by binding to specific receptors on osteoclasts. Additionally, higher FSH levels have been associated with worse metabolic and cardiovascular outcomes, suggesting a possible impact on the cardiovascular system. FSH has also been implicated in immune response modulation, as FSHRs are expressed on immune cells and may influence inflammatory response. Furthermore, there is growing interest in the role of FSH in prostate cancer progression. This paper aims to provide a comprehensive analysis of the literature on the extra-gonadal effects of FSH in men, with a focus on the often-conflicting results reported in this field. Despite the contradictory findings, the potential for future development in this area is substantial, and further research is needed to elucidate the mechanisms underlying these effects and their clinical implications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| العلاقة: | https://www.mdpi.com/1424-8247/16/6/813Test; https://doaj.org/toc/1424-8247Test |
| DOI: | 10.3390/ph16060813 |
| الوصول الحر: | https://doaj.org/article/6d22911f04524499841abc259ec486f5Test |
| رقم الانضمام: | edsdoj.6d22911f04524499841abc259ec486f5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph16060813 |