On the Breakage of High Aspect Ratio Crystals in Filter Beds under Continuous Percolation
| العنوان: | On the Breakage of High Aspect Ratio Crystals in Filter Beds under Continuous Percolation |
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| المؤلفون: | Faiz M. Mahdi, Frans L. Muller, I.S. Fragkopoulos, James Carr, Parmesh Gajjar, A. P. Shier |
| المصدر: | Pharmaceutical Research Mahdi, F M, Shier, A P, Fragkopoulos, I S, Carr, J, Gajjar, P & Muller, F L 2020, ' On the breakage of high aspect ratio crystals in filter beds under continuous percolation ', Pharmaceutical Research, vol. 37, no. 12 . https://doi.org/10.1007/s11095-020-02958-xTest |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Work (thermodynamics), Materials science, Chemistry, Pharmaceutical, Drug Compounding, Pharmaceutical Science, 02 engineering and technology, 010402 general chemistry, pharmaceutical materials, 01 natural sciences, law.invention, Crystal, symbols.namesake, percolation, Breakage, law, Fluid dynamics, Pressure, Pharmacology (medical), Composite material, Particle Size, Filtration, Pharmacology, X-ray computed tomography (XCT), crystal breakage, Organic Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Gibbs free energy, Solutions, Percolation, symbols, Hydrodynamics, Molecular Medicine, Particle size, 0210 nano-technology, Crystallization, pressure filtration, Biotechnology, Research Paper |
| الوصف: | Purpose This work details experimental observations on the effect of liquid flow percolating through packed beds of crystals to elucidate how the filtration pressure severely alters the size distribution and crystal shape. Pressure filtration is widely used in the pharmaceutical industry, and frequently results in undesired size distribution changes that hinder further processing. Methods The percolation methodology presented fixes fluid flow through a bed of crystals, resulting in a pressure over the bed. X-ray computed tomography (XCT) provided detailed observations of the bed structure. Detailed 2D particle size data was obtained using automated microscopy and was analysed using an in-house developed tool. Results Crystal breakage is observed when the applied pressure exceeds a critical pressure: 0.5–1 bar for ibuprofen, 1–2 bar for β-L glutamic acid (LGA) and 2–2.5 bar for para amino benzoic acid (PABA). X-ray computed tomography showed significant changes in bed density under the applied pressure. Size analysis and microscope observations showed two modes of breakage: (i) snapping of long crystals and (ii) shattering of crystals. Conclusion LGA and PABA have a similar breakage strength (50 MPa), ibuprofen is significantly weaker (9 MPa). Available breakage strength data may be correlated to the volumetric Gibbs free energy. Data from 12 and 35 mm bed diameters compares well to literature data in a 80 mm filter; the smaller, easy to operate percolation unit is a versatile tool to assess crystal breakage in filtration operations. |
| وصف الملف: | application/pdf |
| تدمد: | 1573-904X 0724-8741 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0541955d1ecc3aa02a86665b27a0373Test https://pubmed.ncbi.nlm.nih.gov/33123816Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e0541955d1ecc3aa02a86665b27a0373 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1573904X 07248741 |
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