التفاصيل البيبلوغرافية
| العنوان: |
Effects of water extract of Cajanus cajan leaves on differentiation and function of primary osteoblasts and osteoclasts in vitro. |
| المؤلفون: |
Jinchao, Zhang, Cuilan, Ba, Xiaoyu, Ji, Shigang, Shen, Mengsu, Yang, Shuxiang, Wang |
| المصدر: |
Pharmaceutical Biology; Sep2009, Vol. 47 Issue 9, p841-846, 6p, 1 Color Photograph, 6 Charts |
| مصطلحات موضوعية: |
PIGEON pea, BONE diseases, RESORPTION (Physiology), VITAMIN D deficiency, OSTEOPOROSIS |
| مستخلص: |
The effects of water extract of Cajanus cajan (L.) Millsp. leaves (WECML) on differentiation and function of primary osteoblasts and osteoclasts were studied. The results indicated that WECML inhibited the proliferation of osteoblasts at higher concentration of 100 μg/mL and the inhibition rate was 12.12%. When its concentration descended to 0.01~10 μg/mL, it turned to stimulate the proliferation of the osteoblasts. The effects of WECML on differentiation of osteoblasts depended on concentrations and time. It promoted the mineralization function of osteoblasts at concentrations of 0.01, 0.1, and 1 μg/mL, but inhibited the mineralization function at concentrations of 10 and 100 μg/mL. It inhibited bone resorption activity as indicated by the dose-dependent reduction in the pit numbers and areas ( P < 0.05). This indicates that the WECML may be a potential source of natural anti-osteoporosis products. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pharmaceutical Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
