In vitroantimicrobial and anti-proliferative activities of plant extracts fromSpathodea campanulata,Ficus bubu,andCarica papaya
| العنوان: | In vitroantimicrobial and anti-proliferative activities of plant extracts fromSpathodea campanulata,Ficus bubu,andCarica papaya |
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| المؤلفون: | Jean Emmanuel Mbosso Teinkela, Etienne Tsamo, Dieudonné Adiogo, Bruno Lenta Ndjakou, Silvère Ngouela, Erik V. Donfack, Franck Meyer, Jules Clément Assob Nguedia, René Wintjens, Anatole Guy Blaise Azebaze |
| المصدر: | Pharmaceutical Biology. 54:1086-1095 |
| بيانات النشر: | Informa UK Limited, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Pharmaceutical Science, Ficus, Context (language use), Microbial Sensitivity Tests, Gram-Positive Bacteria, Caricaceae, 03 medical and health sciences, Anti-Infective Agents, Cell Line, Tumor, Gram-Negative Bacteria, Drug Discovery, Botany, Humans, Medicinal plants, Medicine, African Traditional, Cell Proliferation, Pharmacology, biology, Traditional medicine, Carica, Plant Extracts, General Medicine, biology.organism_classification, Antimicrobial, Moraceae, Antineoplastic Agents, Phytogenic, 030104 developmental biology, Complementary and alternative medicine, Bignoniaceae, Molecular Medicine, Spathodea |
| الوصف: | African medicinal plants represent a prominent source of new active substances. In this context, three plants were selected for biological investigations based on their traditional uses.The antimicrobial and anti-proliferative features of three plants used for medicinal purpose were evaluated.The antimicrobial activities of methanol extracts of Ficus bubu Warb. (Moraceae) stem bark and leaves, of Spathodea campanulata P. Beauv. (Bignoniaceae) flowers, as well as those of Carica papaya Linn. (Caricaceae) latex, were determined using the microbroth dilution method against a set of bacteria and fungi pathogens including: Enterococcus faecalis, Staphylococcus aureus, S. saprophyticus, S. epidermididis, Escherichia coli, Klebsiella pneumonia, Salmonella typhimurium, Candida albicans, and Trichophyton rubrum. The tested concentrations of extracts ranged from 2500.0 to 2.4 μg/mL and MIC values were evaluated after 24 h incubation at 37 °C. Subsequently, MTT assay was used to estimate anti-proliferative activity of these methanol extracts and of F. bubu latex on three human cancer cell lines (U373 glioblastoma, A549 NSCLC, and SKMEL-28 melanoma).The methanol extract of F. bubu stem bark exhibited the highest antimicrobial activity against C. albicans with a MIC value of 9.8 μg/mL, while the F. bubu latex and the methanol extract of F. bubu leaves induced significant anti-proliferative activity against lung (IC50 values of 10 and 14 μg/mL, respectively) and glioma (IC50 values of 13 and 16 μg/mL, respectively) cancer cells.These results indicate that effective drugs could be derived from the three studied plants. |
| تدمد: | 1744-5116 1388-0209 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633104dc8dccc7098cbae4c9fd1372fcTest https://doi.org/10.3109/13880209.2015.1103273Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....633104dc8dccc7098cbae4c9fd1372fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17445116 13880209 |
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