التفاصيل البيبلوغرافية
| العنوان: |
Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation. |
| المؤلفون: |
Oba, Utako, Yamada, Hiroshi, Suenobu, So‐ichi, Nakamura, Yusuke, Ito, Akiko, Hatano, Yutaka, Itonaga, Nobuyoshi, Ohshima, Kouichi, Koga, Yuhki, Ohga, Shouichi, Ihara, Kenji |
| المصدر: |
Pediatric Transplantation; Aug2017, Vol. 21 Issue 5, pn/a-N.PAG, 4p |
| مصطلحات موضوعية: |
TOXIC epidermal necrolysis, HEMATOPOIETIC stem cell transplantation, DRUG side effects, CD8 antigen, KERATINOCYTES |
| مستخلص: |
TEN is a rare and critical disease mostly caused by drugs. It is mediated by activated CD8+ T cells that cause keratinocyte apoptosis with the assistance of cytokines/chemokines. We herein report a pediatric case of TEN after allogeneic HSCT with precursor B-cell acute lymphoblastic leukemia (pre-B- ALL) in second complete remission. Although we did not evaluate the T-cell subpopulation in blood or skin lesion of the patient, an imbalanced immune reconstitution after HSCT might additively contribute to the development of TEN. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
