التفاصيل البيبلوغرافية
| العنوان: |
Intracranial Empyemas in the COVID-19 Era: A New Phenomenon? A Paediatric Case Series and Review of the Literature. |
| المؤلفون: |
Hall, Benjamin J.1 (AUTHOR), Duddy, John C.1 (AUTHOR), Apostolopoulou, Katerina1 (AUTHOR), David, Raenette1 (AUTHOR), Kurzbuch, Arthur1 (AUTHOR), Nadkarni, Abhishek1 (AUTHOR), Trichinopoly Krishna, Sandhya1 (AUTHOR), Cooper, Ben1 (AUTHOR), Gouldbourne, Hayley1 (AUTHOR), Hennigan, Dawn1 (AUTHOR), Dawes, William1 (AUTHOR), Ellenbogen, Jonathan1 (AUTHOR), Parks, Christopher1 (AUTHOR), Pettorini, Benedetta1 (AUTHOR), Sinha, Ajay1 (AUTHOR), Mallucci, Conor1 (AUTHOR) |
| المصدر: |
Pediatric Neurosurgery. 2023, Vol. 58 Issue 4, p215-222. 8p. |
| مصطلحات موضوعية: |
*COVID-19 pandemic, *LITERATURE reviews, *EMPYEMA, *COVID-19, *CRANIAL sinuses, *DIAGNOSTIC use of polymerase chain reaction |
| مستخلص: |
Introduction: We present the largest series of paediatric intracranial empyemas occurring after COVID-19 infection to date, and discuss the potential implications of the pandemic on this neurosurgical pathology. Methods: Patients admitted to our centre between January 2016 and December 2021 with a confirmed radiological diagnosis of intracranial empyema were retrospectively reviewed, excluding non-otorhinological source cases. Patients were grouped according to onset before or after onset of the COVID-19 pandemic and COVID-19 status. A literature review of all post-COVID-19 intracranial empyemas was performed. SPSS v27 was used for statistical analysis. Results: Sixteen patients were diagnosed with intracranial empyema: n = 5 prior to 2020 and n = 11 after, resulting in an average annual incidence of 0.3% prior to onset of the pandemic and 1.2% thereafter. Of those diagnosed since the pandemic, 4 (25%) were confirmed to have COVID-19 on recent PCR test. Time from COVID-19 infection until empyema diagnosis ranged from 15 days to 8 weeks. Mean age for post-COVID-19 cases was 8.5 years (range: 7–10 years) compared to 11 years in non-COVID cases (range: 3–14 years). Streptococcus intermedius was grown in all cases of post-COVID-19 empyema, and 3 of 4 (75%) post-COVID-19 cases developed cerebral sinus thromboses, compared to 3 of 12 (25%) non-COVID-19 cases. All cases were discharged home with no residual deficit. Conclusion: Our post-COVID-19 intracranial empyema series demonstrates a greater proportion of cerebral sinus thromboses than non-COVID-19 cases, potentially reflecting the thrombogenic effects of COVID-19. Incidence of intracranial empyema at our centre has increased since the start of the pandemic, causes of which require further investigation and multicentre collaboration. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
