Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes
| العنوان: | Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes |
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| المؤلفون: | Laura Pyle, Miguel A. Lanaspa, David M. Maahs, Franziska K. Bishop, Carlos Roncal, Linh T. Chung, Carissa Vinovskis, Richard J. Johnson, Petter Bjornstad, Pattara Wiromrat, Raj Paul Wadwa, Tyler Reznick-Lipina, David Z. Cherney |
| المصدر: | Pediatr Diabetes |
| بيانات النشر: | Hindawi Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Renal function, 030209 endocrinology & metabolism, Article, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Vascular Stiffness, 0302 clinical medicine, Copeptin, Internal medicine, Heart rate, Internal Medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, 030212 general & internal medicine, Child, Pulse wave velocity, Creatinine, Type 1 diabetes, biology, business.industry, Glycopeptides, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Cystatin C, Case-Control Studies, Pediatrics, Perinatology and Child Health, Cardiology, Arterial stiffness, biology.protein, Female, business, Biomarkers |
| الوصف: | OBJECTIVE We sought to evaluate copeptin concentrations in adolescents with and without type 1 diabetes (T1D) and examine the associations between copeptin and measures of arterial stiffness and kidney dysfunction. RESEARCH DESIGN AND METHODS This analysis included 169 adolescents with T1D (12-19 years of age, 59% girls, mean HbA1c 9.0 ± 1.5% and diabetes duration of 8.6 ± 2.9 years), in addition to 61 controls without T1D. Arterial stiffness including carotid-femoral pulse wave velocity (CF-PWV), carotid-radial PWV (CR-PWV), augmentation index normalized to heart rate of 75 bpm (AIx@HR75), and brachial artery distensibility (BAD). Serum copeptin, urinary albumin-to-creatinine ratio (UACR), and estimated glomerular filtration rate (eGFR) by serum creatinine and cystatin C were also assessed. RESULTS Compared to controls, adolescents with T1D had higher median (Q1-Q3) copeptin (7.5 [5.2-11.3] vs 6.4 [4.8-8.3] pmol/L, P = .01), mean ± SD eGFR (121 ± 23 vs 112 ± 16 mL/min/1.73m2 , P = .002) and lower BAD (7.1 ± 1.3 vs 7.2 ± 1.2%, P = .02). Adolescents with T1D in the in high tertile copeptin group (>9.1 pmol/L) had higher AIx@HR75 (10.7 ± 1.2 vs 5 ± 1.2, P = .001), CR-PWV (5.30 ± 1.0 vs 5.18 ± 1.0 m/s, P = .04), and UACR (12 ± 1 vs 8 ± 1 mg/g, P = .025) compared to those in low tertile ( |
| تدمد: | 1399-5448 1399-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ace5f78bf1fa2b2133ab1e24b8a29aTest https://doi.org/10.1111/pedi.12909Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....33ace5f78bf1fa2b2133ab1e24b8a29a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13995448 1399543X |
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