التفاصيل البيبلوغرافية
| العنوان: |
HLA-typing, clinical, and immunological characterization of youth with type 2 diabetes mellitus phenotype from the German/Austrian DPV database. |
| المؤلفون: |
Awa, Wendy L, Boehm, Bernard O, Rosinger, Silke, Achenbach, Peter, Ziegler, Anette G, Krause, Stephanie, Meissner, Thomas, Wiegand, Susanne, Reinehr, Thomas, Kapellen, Thomas, Karges, Beate, Eiermann, Thomas, Schober, Edith, Holl, Reinhard W |
| المصدر: |
Pediatric Diabetes; Dec2013, Vol. 14 Issue 8, p562-574, 13p, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
AUTOANTIBODY analysis, BLOOD sugar analysis, TYPE 2 diabetes diagnosis, TYPE 2 diabetes treatment, OBESITY, ADIPOSE tissues, ANTHROPOMETRY, C-peptide, DATABASES, GLYCOSYLATED hemoglobin, HIGH density lipoproteins, IMMUNITY, INFORMED consent (Medical law), INSULIN, LOW density lipoproteins, TYPE 2 diabetes, PEDIATRICS, PROTEINS, QUESTIONNAIRES, HLA-B27 antigen, PHENOTYPES, COMORBIDITY, BODY mass index, METFORMIN, DIAGNOSIS, ANATOMY |
| مصطلحات جغرافية: |
AUSTRIA, GERMANY |
| مستخلص: |
Aim To characterize the clinical and immunological features of HLA-typed youth with pediatric onset of type 2 diabetes mellitus ( T2DM). Method One hundred and seven patients with clinically diagnosed T2DM (aged ≤20 yr at diagnosis) were examined. DNA and serum, obtained after a median diabetes duration of 2.2 ( Q1-Q3: 0.8-4.6) yr, were used for centralized HLA-typing and autoantibody ( GADA, IA-2A, ZnT8A) measurements. Results 64.6% of patients were female and median age at diagnosis was 13.8 ( Q1-Q3: 11.6-15.4) yr. Patients were obese [median body mass index-standard deviation score ( BMI-SDS): 2.6 (2.0-3.1)], 88.0% had a family history of diabetes and 40.2% a migration background. Islet autoantibodies were detected in 16 (15.0%), among which 7 (6.5%) had multiple islet autoantibodies. Autoantibody positive patients had poorer metabolic control than autoantibody negative patients [glycosylated hemoglobin A1c ( HbA1c): 8.1 (6.9-10.1) % vs. 6.6 (5.9-8.0) %; p = 0.033], while patients with HLA-DR genetic risk had higher BMI-SDS than those with HLA-DRXX [2.6 (2.4-3.7) vs. 2.4 (1.7-2.9); p = 0.007]. Metabolic syndrome (61.7%), microalbuminuria (13.4%), and retinopathy (3.9%) were diagnosed. Therapies used were lifestyle only (35.5%), oral anti-diabetics ( OAD) only (43.3 %), insulin + OAD (15.9%) and insulin only (5.6%). Patients with β-cell autoimmunity or HLA-DR genetic risk more frequently used insulin than confirmed T2DM patients (50.0 vs. 22.0%; p = 0.037) and less often had diabetic relatives (61.1 vs. 86.0%; p = 0.030). Conclusion T2DM was confirmed in about 90% of patients while about 10% with β-cell autoimmunity or HLA-DR genetic risk likely had either T1. 5DM or 'double diabetes' or an unknown diabetes type. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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