المؤلفون: Barbara C. Galland, Esko Wiltshire, Jenny Rayns, James Stanley, Shelley Rose, Martin de Bock, Karen E MacKenzie, Sara E Boucher, Claire Smith, Benjamin J Wheeler

المصدر: Pediatric Diabetes. 22:823-831

مصطلحات موضوعية: Adult, Blood Glucose, Male, Pediatrics, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Glycemic Control, Pittsburgh Sleep Quality Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Sleep debt, Risk Factors, Diabetes management, Diabetes mellitus, Internal Medicine, Humans, Medicine, 030212 general & internal medicine, Glycemic, Glycated Hemoglobin, Type 1 diabetes, business.industry, Actigraphy, medicine.disease, Sleep in non-human animals, Diabetes Mellitus, Type 1, Sleep Quality, Case-Control Studies, Pediatrics, Perinatology and Child Health, Female, Sleep, business, New Zealand

الوصف: BACKGROUND In type 1 diabetes mellitus (T1D), glycemic control and sleep have a bidirectional relationship, with unhealthy glycemic control impacting sleep, and inadequate sleep impacting diabetes management. Youth are at risk for poor quality sleep; however, little is known about sleep among youth with high-risk glycemic control. OBJECTIVE To assess differences in habitual sleep timing, duration, and quality among youth with T1D and controls. SUBJECTS Two-hundred-thirty youth (13-20 years): 64 with T1D (mean age 16.6 ± 2.1 years, 48% female, diabetes duration 7.5 ± 3.8 years, HbA1c 96 ± 18.0 mmol/mol [10.9 ± 1.7%]), and 166 controls (mean age 15.3 ± 1.5, 58% female). METHODS Comparison of data from two concurrent studies (from the same community) using subjective and objective methods to assess sleep in youth: Pittsburgh Sleep Quality Index evaluating sleep timing and quality; 7-day actigraphy measuring habitual sleep patterns. Regression analyses were used to compare groups. RESULTS When adjusted for various confounding factors, youth with T1D reported later bedtimes (+36 min; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a36ad3802ba9ccf652e929bab8b82acTest
https://doi.org/10.1111/pedi.13215Test

المؤلفون: A.T. Sidibé, Sandy Jl, M. Minkailou, S. Besançon, A. Togo, Ogle Gd

المصدر: Pediatric Diabetes. 22:545-551

مصطلحات موضوعية: Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Health Promotion, Mali, Young Adult, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Diabetes mellitus, Prevalence, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Age of Onset, Sex Distribution, Child, education, Type 1 diabetes, education.field_of_study, Education campaign, business.industry, Incidence, Mortality rate, Incidence (epidemiology), Infant, medicine.disease, Survival Rate, Diabetes Mellitus, Type 1, Standardized mortality ratio, Observed Incidence, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business

الوصف: AIMS Determine incidence, prevalence and mortality of Type 1 diabetes (T1D) in children and youth

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fef10ff35afacb7f9fa72572156cc3Test
https://doi.org/10.1111/pedi.13191Test

المؤلفون: William H. Lagarde, Eva Tsalikian, Kimberly Steinmann, Barry Reiner, Steven M. Willi, Kecia L. Courtney

المصدر: Pediatric Diabetes

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Serine Proteinase Inhibitors, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Placebo, Gastroenterology, Proof of Concept Study, Drug Administration Schedule, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Internal medicine, Internal Medicine, medicine, Humans, In patient, 030212 general & internal medicine, Dosing, Interleukin 6, Child, Infusions, Intravenous, Type 1 diabetes, biology, C-Peptide, C-peptide, business.industry, C‐peptide, Interleukin-6, Insulin, Type 1 Diabetes: Pathophysiology and Prevention, alpha 1‐proteinase inhibitor, prolastin, medicine.disease, Diabetes Mellitus, Type 1, Treatment Outcome, chemistry, Tolerability, Interleukin‐6, alpha 1-Antitrypsin, Pediatrics, Perinatology and Child Health, biology.protein, Female, business

الوصف: Background While circulating levels of alpha1‐proteinase inhibitor (alpha1‐PI) are typically normal, antiprotease activity appears to be compromised in patients with Type 1 diabetes mellitus (T1DM). Because alpha1‐PI [human] (alpha1‐PI[h]) therapy can inhibit pro‐inflammatory mediators associated with β‐cell destruction and reduced insulin production, it has been proposed for T1DM disease prevention. The aim of this study was to evaluate safety, tolerability, and efficacy of intravenous (IV) alpha1‐PI[h] in preserving C‐peptide production in newly diagnosed T1DM patients. Participants Seventy‐six participants (aged 6–35 years) were randomized at 25 centers within 3 months of T1DM diagnosis. Methods A Phase II, multicenter, partially blinded, placebo‐controlled, proof‐of‐concept study evaluating four dosing regimens of alpha1‐PI[h] (NCT02093221, GTI1302): weekly IV infusions of either 90 or 180 mg/kg, each for either 13 or 26 weeks. Safety and efficacy were monitored over 52 weeks with an efficacy evaluation planned at 104 weeks. The primary efficacy endpoint was change from baseline in the 2‐h area‐under‐the‐curve C‐peptide level from a mixed‐meal tolerance test at 52 weeks. A battery of laboratory tests, including inflammatory biomarkers, constituted exploratory efficacy variables. Results Infusions were well tolerated with no new safety signals. All groups exhibited highly variable declines in the primary outcome measure at 52 weeks with no statistically significant difference from placebo. Interleukin‐6 (IL‐6) was reduced from baseline in all alpha1‐PI treatment groups but not the placebo group. Conclusion Pharmacologic therapy with alpha1‐PI[h] is safe, well tolerated, and able to reduce IL‐6 levels; however, due to variability in the efficacy endpoint, its effects on preservation of C‐peptide production were inconclusive.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a4f2a395371627eefdb01a08bfa44aTest
http://europepmc.org/articles/PMC7984376Test

المؤلفون: Feyza Darendeliler, Zehra Aycan, Ecem Can, Nazan Yardim, Şükrü Hatun, Melek Bulanık, Tuğba Gökçe, Murat Gülşen, Gül Yeşiltepe Mutlu, Sibel Sakarya, Mehmet Fatih Kurtulmuş, Kardelen Cemhan, Serra Muradoğlu, Özlem Ülger

المصدر: Pediatric Diabetes. 22:233-240

مصطلحات موضوعية: Adult, Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Turkey, Inequality, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, education, Childhood diabetes, Psychological intervention, 030209 endocrinology & metabolism, Young Adult, 03 medical and health sciences, School nurse, 0302 clinical medicine, Surveys and Questionnaires, Diabetes mellitus, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Aged, School Health Services, media_common, Type 1 diabetes, business.industry, Knowledge level, Middle Aged, medicine.disease, Faculty, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Family medicine, Pediatrics, Perinatology and Child Health, Female, School Teachers, business, Regional differences

الوصف: The aim of this study was to measure the knowledge and attitudes of school staff regarding care in school for children with type 1 diabetes and to evaluate the contribution of the "Diabetes Program at School"(DPS). The data were collected through an online survey consisting of 55 questions, which included 39 knowledge and 16 attitude questions. The survey was delivered to the participating school staff via a link. A total of 55,677 people who completed 100% of the survey were included. Of the participants, 76% were teachers, 23% were school administrators and 0.1% were school nurses. 73% (40732) of the participants stated that they had heard about the "DPS". Of the participants who were aware of the DPS 75%, 50%, and 41% stated an increase in their knowledge level, self-confidence, and awareness respectively. Both scores were positively associated with being female and school nurse, having students with diabetes in the school, having been trained in childhood diabetes, being familiar with the program and being from the Western region of Turkey. The DPS is well known among school staff including teachers, school administrators, and school nurses. However, there are clear regional differences in the knowledge and attitude of school staff regarding diabetes care at school. Therefore, regional differences should be taken into account when planning the necessary interventions to prevent any further increase in the current inequalities. In addition, increasing the number of school nurses, together with strengthening the knowledge and attitude of school staff, can improve the level of diabetes care at school.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286b8a2d6931fe70aa4624c9da35f637Test
https://doi.org/10.1111/pedi.13157Test

المؤلفون: Michael C. Riddell, Louisa van den Boom, Simon Heller, Peter G. Jacobs, Richard M. Bergenstal, Pieter Gillard, Carine de Beaufort, Martin Tauschmann, Max L. Eckstein, Tadej Battelino, Othmar Moser, Chantal Mathieu, Dessi P. Zaharieva, Richard M. Bracken, Harald Sourij, Peter Adolfsson, Carmel E. Smart, Nick Oliver, Christoph Stettler, Hood Thabit, Rémi Rabasa-Lhoret, Tim Heise, Julia K. Mader, Eda Cengiz, Lalantha Leelarathna, Aaron J. Kowalski, Kirsten Nørgaard, Bruce A. Buckingham, Asma Deeb, Emma G. Wilmot

المساهمون: Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Diabetes Clinic

المصدر: Pediatric Diabetes
Moser, Othmar; Riddell, Michael C; Eckstein, Max L; Adolfsson, Peter; Rabasa-Lhoret, Rémi; van den Boom, Louisa; Gillard, Pieter; Nørgaard, Kirsten; Oliver, Nick S; Zaharieva, Dessi P; Battelino, Tadej; de Beaufort, Carine; Bergenstal, Richard M; Buckingham, Bruce; Cengiz, Eda; Deeb, Asma; Heise, Tim; Heller, Simon; Kowalski, Aaron J; Leelarathna, Lalantha; ... (2020). Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA). Pediatric diabetes, 21(8), pp. 1375-1393. Wiley 10.1111/pedi.13105 <http://dx.doi.org/10.1111/pedi.13105Test>
Diabetolegia

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Endocrinology, Diabetes and Metabolism, Position statement, Adolescents, 0302 clinical medicine, Exercise/physiology, Insulin, 610 Medicine & health, Child, Children, Continuous glucose monitoring, Quality Of Life, Diabetes Mellitus, Type 1/physiopathology, Glucose management, Type 1 diabetes, Adult, medicine.medical_specialty, Adolescent, Diabetes Mellitus, Type 1/drug therapy, 030209 endocrinology & metabolism, Physical exercise, Glycemic Control, 03 medical and health sciences, Diabetes mellitus, Internal Medicine, medicine, Adults, Humans, Hypoglycemic Agents, Pediatrics, Perinatology, and Child Health, Exercise, American diabetes association, Health professionals, Blood Glucose/metabolism, business.industry, CGM, Physical activity, Blood Glucose Self-Monitoring, medicine.disease, Hypoglycemic Agents/administration & dosage, 030104 developmental biology, Diabetes Mellitus, Type 1, Physical therapy, Ispad Guidelines, Glycemic Control/methods, business, Insulin/administration & dosage

الوصف: Physical exercise is an important component in the management of type 1 diabetes across the lifespan. Yet, acute exercise increases the risk of dysglycaemia, and the direction of glycaemic excursions depends, to some extent, on the intensity and duration of the type of exercise. Understandably, fear of hypoglycaemia is one of the strongest barriers to incorporating exercise into daily life. Risk of hypoglycaemia during and after exercise can be lowered when insulin-dose adjustments are made and/or additional carbohydrates are consumed. Glycaemic management during exercise has been made easier with continuous glucose monitoring (CGM) and intermittently scanned continuous glucose monitoring (isCGM) systems; however, because of the complexity of CGM and isCGM systems, both individuals with type 1 diabetes and their healthcare professionals may struggle with the interpretation of given information to maximise the technological potential for effective use around exercise (ie, before, during and after). This position statement highlights the recent advancements in CGM and isCGM technology, with a focus on the evidence base for their efficacy to sense glucose around exercise and adaptations in the use of these emerging tools, and updates the guidance for exercise in adults, children and adolescents with type 1 diabetes. ispartof: PEDIATRIC DIABETES vol:21 issue:8 pages:1375-1393 ispartof: location:Denmark status: published

وصف الملف: application/pdf; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e8f226f623aa0eb01f9012920db823Test
http://europepmc.org/articles/PMC7702152Test

المؤلفون: Andrew Neil, Kim C. Donaghue, Sally M. Marshall, Maria E. Craig, Jennifer J Couper, Paul M. McKeigue, Fergus J. Cameron, Denis Daneman, Timothy W. Jones, Paul Z. Benitez-Aguirre, Marco Colombo, Scott T Chiesa, Elizabeth A. Davis, Helen M. Colhoun, David B. Dunger, M. L. Marcovecchio, John E. Deanfield, Farid H. Mahmud, Raymond Neil Dalton

المصدر: 2020, ' Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes ', Pediatric Diabetes . https://doi.org/10.1111/pedi.13095Test

مصطلحات موضوعية: Adult, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Renal function, 030209 endocrinology & metabolism, Gastroenterology, Nephropathy, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Diabetic Nephropathies, 030212 general & internal medicine, Cystatin C, Child, Type 1 diabetes, biology, business.industry, Age Factors, Middle Aged, medicine.disease, Fibroblast Growth Factors, Fibroblast Growth Factor-23, Diabetes Mellitus, Type 1, Pediatrics, Perinatology and Child Health, biology.protein, Biomarker (medicine), Osteopontin, Microalbuminuria, Trefoil Factor-3, beta 2-Microglobulin, business, Biomarkers, Glomerular Filtration Rate

الوصف: OBJECTIVES: To identify biomarkers of renal disease in adolescents with type 1 diabetes (T1D) and to compare findings in adults with T1D.METHODS: Twenty-five serum biomarkers were measured, using a Luminex platform, in 553 adolescents (median [interquartile range] age: 13.9 [12.6, 15.2] years), recruited to the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial. Associations with baseline and final estimated glomerular filtration rate (eGFR), rapid decliner and rapid increaser phenotypes (eGFR slopes 3 mL/min/1.73m2 /year, respectively), and albumin-creatinine ratio (ACR) were assessed. Results were also compared with those obtained in 859 adults (age: 55.5 [46.1, 64.4) years) from the Scottish Diabetes Research Network Type 1 Bioresource.RESULTS: In the adolescent cohort, baseline eGFR was negatively associated with trefoil factor-3, cystatin C, and beta-2 microglobulin (B2M) (B coefficient[95%CI]: -0.19 [-0.27, -0.12], P = 7.0 × 10-7 ; -0.18 [-0.26, -0.11], P = 5.1 × 10-6 ; -0.12 [-0.20, -0.05], P = 1.6 × 10-3 ), in addition to clinical covariates. Final eGFR was negatively associated with osteopontin (-0.21 [-0.28, -0.14], P = 2.3 × 10-8 ) and cystatin C (-0.16 [-0.22, -0.09], P = 1.6 × 10-6 ). Rapid decliner phenotype was associated with osteopontin (OR: 1.83 [1.42, 2.41], P = 7.3 × 10-6 ), whereas rapid increaser phenotype was associated with fibroblast growth factor-23 (FGF-23) (1.59 [1.23, 2.04], P = 2.6 × 10-4 ). ACR was not associated with any of the biomarkers. In the adult cohort similar associations with eGFR were found; however, several additional biomarkers were associated with eGFR and ACR.CONCLUSIONS: In this young population with T1D and high rates of hyperfiltration, osteopontin was the most consistent biomarker associated with prospective changes in eGFR. FGF-23 was associated with eGFR increases, whereas trefoil factor-3, cystatin C, and B2M were associated with baseline eGFR.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee30256d16fc43d8d9c64c93a523b734Test
https://doi.org/10.1111/pedi.13095Test

المؤلفون: Line Quist Bendtsen, Hanne Haahr, Mette Dahl Bendtsen, Thekla von dem Berge, Naveen Rathor, Torben Biester, Thomas Danne

المصدر: Pediatric Diabetes

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Clinical Care and Technology, Adolescent, endocrine system diseases, Drug Compounding, Insulin Antibodies, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Gastroenterology, Insulin aspart, Young Adult, 03 medical and health sciences, 0302 clinical medicine, children, Pharmacokinetics, Internal medicine, pharmacodynamics, Internal Medicine, medicine, Humans, adolescents, 030212 general & internal medicine, Child, Insulin Aspart, Type 1 diabetes, Cross-Over Studies, biology, business.industry, Insulin, Age Factors, nutritional and metabolic diseases, Middle Aged, medicine.disease, Crossover study, Diabetes Mellitus, Type 1, Postprandial, Pharmacodynamics, Pediatrics, Perinatology and Child Health, biology.protein, Female, Antibody, business, pharmacokinetics, medicine.drug

الوصف: Background Fast‐acting insulin aspart (faster aspart) is a novel formulation of insulin aspart (IAsp) ensuring ultrafast absorption and effect. Aim To compare the pharmacokinetics between faster aspart and IAsp, based on free or total IAsp measurement, and investigate the association between anti‐IAsp antibodies and faster aspart and IAsp pharmacological properties in children and adolescents with type 1 diabetes (T1D). Methods In a randomized, two‐period crossover trial, 12 children, 16 adolescents, and 15 adults (6‐11, 12‐17, and 18‐64 years) received 0.2 U/kg double‐blindsingle‐dose subcutaneous faster aspart or IAsp followed by a standardized liquid meal test. Results Across age groups, the pharmacokinetic profile was left‐shifted including greater early exposure for faster aspart vs IAsp irrespective of free or total IAsp assay. Onset of appearance occurred 2.4 to 5.0 minutes (free) or 1.8 to 3.0 minutes (total) earlier for faster aspart vs IAsp (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79365e565bd133170b3fb1012daeb48aTest
https://doi.org/10.1111/pedi.13026Test

المؤلفون: Lina Merjaneh, Dana Dabelea, Jeanette M. Stafford, Santica M. Marcovina, Lawrence M. Dolan, Ralph B. D'Agostino, Jean M. Lawrence, Amy K. Mottl, Evgenia Gourgari, Amy S. Shah

المصدر: Pediatr Diabetes

مصطلحات موضوعية: Adult, Mean arterial pressure, medicine.medical_specialty, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Article, Cohort Studies, Young Adult, 03 medical and health sciences, Vascular Stiffness, 0302 clinical medicine, Insulin resistance, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Age of Onset, Glycated Hemoglobin, Waist-to-height ratio, Type 1 diabetes, business.industry, Age Factors, nutritional and metabolic diseases, Cholesterol, LDL, medicine.disease, Obesity, United States, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Heart Disease Risk Factors, Pediatrics, Perinatology and Child Health, Arterial stiffness, Cardiology, Insulin Resistance, business, Diabetic Angiopathies

الوصف: Aim Our aim was to explore the relationship of Low-Density Lipoprotein Cholesterol (LDL-C) with subclinical cardiovascular disease (CVD) in youth with T1D and T2D. We hypothesized the association of LDL-C with elevated arterial stiffness (AS) would be partially accounted by the co-occurrence of other CVD factors. Method We included 1376 youth with T1D and 157 with T2D from the SEARCH study. CVD risk factors including LDL-C, waist to height ratio (WHtR), mean arterial pressure (MAP), HbA1c, albumin to creatinine ratio (ACR), and insulin sensitivity (IS) score were measured at both visits. At follow up, elevated carotid-femoral AS was defined as levels above 6.8 m/s. Multivariable logistic regression evaluated the odds of elevated AS as a function of the average CVD risk factors. Results At follow up, age was 18.0 ± 4.1 and 21.6 ± 3.5 years and duration of diabetes was 7.8 ± 1.9 and 7.7 ± 1.9 years in T1D and T2D, respectively. Elevated AS was found in 8.4% of T1D and 49.0% of T2D participants. Each SD increase in LDL-C was associated with 1.28 increased odds (95% CI 1.05-1.54, P = .013) of elevated AS in youth with T1D. The association was similar but not statistically significant in T2D. WHtR, IS, and MAP were associated with elevated AS in both groups. Adjustment for WHtR or IS attenuated to non-significance the relationship between LDL-C and AS in T1D. Conclusions Obesity and insulin resistance attenuate the association of high LDL-C with AS suggesting they partially account for the adverse effects of LDL-C on cardiovascular health in youth with T1D.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b9659bb75725f77237a38e93291744Test
https://doi.org/10.1111/pedi.13021Test

المؤلفون: Brynn E. Marks, Joseph I. Wolfsdorf, Gretchen Waldman, Kathleen Reardon, Anshul Kumar, Katharine C. Garvey, Diane E J Stafford, Shannon Terrio

المصدر: Pediatric Diabetes. 21:814-823

مصطلحات موضوعية: Adult, Male, Insulin pump, Health Knowledge, Attitudes, Practice, Technology, medicine.medical_specialty, Pediatric endocrinology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, education, Graduate medical education, 030209 endocrinology & metabolism, Pediatrics, Education, Distance, 03 medical and health sciences, Endocrinology, Insulin Infusion Systems, 0302 clinical medicine, Inventions, Internal Medicine, medicine, Humans, Medical physics, 030212 general & internal medicine, Child, Curriculum, Type 1 diabetes, business.industry, Blood Glucose Self-Monitoring, Insulin, Internship and Residency, medicine.disease, Diabetes Mellitus, Type 1, Pediatrics, Perinatology and Child Health, Female, Glucose monitors, Thematic analysis, business, Computer-Assisted Instruction

الوصف: OBJECTIVE We explored the impact of TeKnO T1D, an online, case-based, spaced education curriculum about insulin pump and continuous glucose monitor (CGM) use in pediatric type 1 diabetes management. METHODS Pediatric endocrinology fellows (n = 64) were randomized to receive an educational curriculum focused on either insulin pumps or CGMs. Fellows received interactive questions twice weekly via email or mobile app. Median time to completion was 76.5 days. The primary outcome was change in knowledge as measured by performance on multiple-choice questions (MCQ) from the pre-test to the post-test. RESULTS Forty-eight of 64 (75%) learners completed the curriculum and assessments. The pump group improved from 35.0 ± 15% on the pre-test MCQs to 61.1 ± 17% on the post-test, a 12.2 absolute percentage point greater improvement on pump-specific items than the CGM group (P = .03). The CGM group improved from 30.3 ± 15% on the pre-test MCQs to 61.4 ± 21% on the post-test, a 28.7 absolute percentage point greater improvement on CGM-specific items than the pump group (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1fd8abceedf64c172e891a44cabfabTest
https://doi.org/10.1111/pedi.13010Test

المؤلفون: Leonilda Maria Barbosa dos Santos, Silvia B. Marques, Candida Parisi, Elizabeth João Pavin, Sofia Helena Valente de Lemos Marini, Fernando Pradella, Emílio Carlos Elias Baracat, Alessandro dos Santos Farias, Maria Fernanda Vanti Macedo Paulino, Carlos Fernando Macedo, Sofia R. Lieber, Daniela da Silva Camilo, Edilaine G. Guariento, Ana Leda F. Longhini, Gil Guerra, Walkyria Mara Gonçalves Volpini, Letícia Gama e Silva

المصدر: Pediatric Diabetes. 21:606-614

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Remission, Spontaneous, 030209 endocrinology & metabolism, Disease, Human leukocyte antigen, Gastroenterology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, immune system diseases, HLA-DQ Antigens, Internal medicine, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, 030212 general & internal medicine, Child, Genotyping, HLA-DRB1, Genetic Association Studies, Autoantibodies, Type 1 diabetes, biology, business.industry, Haplotype, Histocompatibility Antigens Class II, Autoantibody, Infant, nutritional and metabolic diseases, medicine.disease, Diabetes Mellitus, Type 1, Haplotypes, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, biology.protein, Female, Antibody, business, Brazil, HLA-DRB1 Chains

الوصف: OBJECTIVE Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. METHODS We analyzed the prevalence of partial remission in 51 new-onset T1D patients with a median time follow-up of 13 months from diagnosis. For this study, anti-GAD65, anti-IA2 and HLA class II genotyping were considered. RESULTS Partial remission occurred in 41.2% of T1D patients until 3 months after diagnosis, mainly in those aged 5-15 years. We have demonstrated a significant increase in the haplotypes of class II HLA DRB1*0301-DQB1*0201 in children and adolescents with a partial remission phase of the disease (42.9% vs 21.7% in non-remitters, P = .0291). This haplotype was also associated with the reduction of anti-IA2 antibodies production. Homozygote DRB1*03-DQB1*0201/DRB1*03-DQB1*0201 children had the lowest prevalence of IA-2A antibodies (P = .0402). However, this association does not correlate with the time of the remission phase. CONCLUSION Although the number of patients studied was reduced, our data suggested that the association between genetics and decrease in antibody production to certain islet auto-antigen may contribute, at least in part, to the remission phase of T1D.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ac391ccba4e931b892cb1ef922e328Test
https://doi.org/10.1111/pedi.12999Test