The Epidemiology of Childhood Alopecia Areata in China: A Study of 226 Patients
| العنوان: | The Epidemiology of Childhood Alopecia Areata in China: A Study of 226 Patients |
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| المؤلفون: | Jiang-Bo Liu, Kai-Lin Yan, Yong Cui, Min Gao, Sen Yang, Xuejun Zhang, J. Yang, Ping-Ping He, Yan-Hua Liang, Feng-Li Xiao |
| المصدر: | Pediatric Dermatology. 23:13-18 |
| بيانات النشر: | Wiley, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Male, China, medicine.medical_specialty, Pediatrics, Adolescent, Alopecia Areata, Dermatology, Severity of Illness Index, Age Distribution, Epidemiology, Prevalence, medicine, Genetic predisposition, Humans, Age of Onset, Sex Distribution, Family history, Child, business.industry, Infant, Alopecia areata, Prognosis, medicine.disease, Surgery, Cross-Sectional Studies, Hair loss, El Niño, Genetic epidemiology, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Age of onset, business |
| الوصف: | To study the clinical and epidemiologic profile of childhood alopecia areata, we performed a survey in which a total of 226 childhood patients less than 16 years old were enrolled. Statistical analysis and herita- bility were performed using EPI INFO 6.0, SPSS10.0, and the Falconer method. The median age of onset was 10 years. The majority of patients (84.96%) pre- sented with limited alopecia. The male : female ratio was 1.4:1. Boys appeared to have more severe involvement. The earlier the age of onset, the greater the severity of the disease. Sixty-seven patients (29.65%) had previous epi- sodes of alopecia areata. Greater severity and longer duration were seen in the relapsing patients than in the primary patients. Six patients (2.65%) had an associated disease. A positive family history was reported in 25 patients (11.06%). The prevalence figures for alopecia areata in first-, second-, and third-degree relatives of the probands were 2.87%, 0.40%, and 0.13%, respec- tively. The heritabilities of AA in first-, second-, and third-degree relatives were 51.20%, 46.25%, and 25.65%, respectively. It can be speculated that the effect of genetic factors is important in the occurrence of this disease. Alopecia areata (AA) usually presents as a sudden onset of patchy, nonscarring hair loss. It is hypothesized to be an organ-specific autoimmune disease with genetic predisposition and an environmental trigger (1). This disease affects both adults and children. We have done a survey of the genetic epidemiology of 1032 patients with AA and concluded that the effect of genetic factors is strong (2). There are limited data on childhood AA (3-5). There are no reports of a large cohort of Chinese children with AA. The purpose of our study was to review the epidemiology, clinical aspects, and complications of AA in Chinese patients less than 16 years old. |
| تدمد: | 1525-1470 0736-8046 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9674e1f30daaa1fa1d747ec01a755151Test https://doi.org/10.1111/j.1525-1470.2006.00161.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9674e1f30daaa1fa1d747ec01a755151 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251470 07368046 |
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