Correction of chronic granulomatous disease after second unrelated‐donor umbilical cord blood transplantation
العنوان: | Correction of chronic granulomatous disease after second unrelated‐donor umbilical cord blood transplantation |
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المؤلفون: | Paul L. Martin, Suhag Parikh, Joanne Kurtzberg, Vinod K. Prasad, Sonali Lakshminarayanan, Paul Szabolcs, Timothy A. Driscoll |
المصدر: | Pediatric Blood & Cancer. 49:982-984 |
بيانات النشر: | Wiley, 2007. |
سنة النشر: | 2007 |
مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Graft vs Host Disease, Cord Blood Stem Cell Transplantation, Hematopoietic stem cell transplantation, Granulocyte, Granulomatous Disease, Chronic, Aspergillosis, Chronic granulomatous disease, Risk Factors, Unrelated Donor, medicine, Humans, Transplantation, Homologous, Child, Umbilical Cord Blood Transplantation, business.industry, Infant, Immunosuppression, Hematology, medicine.disease, Surgery, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, Oncology, Pediatrics, Perinatology and Child Health, business, Follow-Up Studies |
الوصف: | Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for chronic granulomatous disease (CGD), but many patients lack a suitably matched related donor. We report successful outcomes after mismatched, unrelated-donor umbilical cord blood transplantation (uUCBT) in two boys with X-linked CGD. Both patients experienced autologous recovery after first transplants, required second transplants to achieve durable donor engraftment, and are alive 27 and 15 months post-transplant. Both had invasive fungal disease and received granulocyte transfusions. In conclusion, uUCBT is effective in children with CGD, but immunosuppression in the conditioning regimen may need to be increased to decrease the risk of graft rejection. |
تدمد: | 1545-5017 1545-5009 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf3caca520a6ea41c5705d9d5de3a07aTest https://doi.org/10.1002/pbc.21365Test |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi.dedup.....bf3caca520a6ea41c5705d9d5de3a07a |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15455017 15455009 |
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