Primary High-Grade B-Cell Lymphoma of the Breast with Concurrent IGH-BCL2 and MYC-IGL Translocations in an Adolescent Patient
| العنوان: | Primary High-Grade B-Cell Lymphoma of the Breast with Concurrent IGH-BCL2 and MYC-IGL Translocations in an Adolescent Patient |
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| المؤلفون: | Loris McGavran, Edythe A. Albano, Amy N. McGranahan, Karen Swisshelm, Ashley E. Jones, Billie Carstens, Lynne Meltesen, Roger Giller, Xiayuan Liang |
| المصدر: | Pediatric and Developmental Pathology. 14:402-406 |
| بيانات النشر: | SAGE Publications, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Lymphoma, B-Cell, Genes, Immunoglobulin Heavy Chain, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Abnormal Karyotype, Breast Neoplasms, Chromosomal translocation, Translocation, Genetic, Pathology and Forensic Medicine, Proto-Oncogene Proteins c-myc, Young Adult, Fatal Outcome, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Neoplasm, Young adult, B-cell lymphoma, Pathological, business.industry, DNA, Neoplasm, General Medicine, Gene rearrangement, medicine.disease, Combined Modality Therapy, Adolescent patient, Lymphoma, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-bcl-2, Pediatrics, Perinatology and Child Health, Female, Genes, Immunoglobulin Light Chain, business |
| الوصف: | BCL2 and MYC are oncogenes often deregulated in lymphomas. Concurrent IGH-BCL2 and MYC translocations result in a highly aggressive behavior of these tumors. Both primary breast lymphoma and lymphoma with concurrent BCL2-IGH and MYC translocations are rare and are primarily seen in adult patients. As a result of limited clinician experience and the condition's rarity, it poses a great challenge to pediatric pathologists and oncologists in terms of making an accurate diagnosis and choosing better treatment regimens. In this article, we report a case of an adolescent patient who presented with high-grade breast lymphoma with concurrent BCL2-IGH and MYC-IGL translocations, and we review the clinical, pathological, and genetic features; management strategies; and outcomes associated with this unusual neoplasm. |
| تدمد: | 1615-5742 1093-5266 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0bc85ef673d254ba6b16eddb136956Test https://doi.org/10.2350/10-10-0927-cr.1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....4a0bc85ef673d254ba6b16eddb136956 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16155742 10935266 |
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