التفاصيل البيبلوغرافية
| العنوان: |
The predictive value of allergen skin prick tests and Ig E tests at pre-school age: The PACT study. |
| المؤلفون: |
Rø, Anne Dorthea1,2, Simpson, Melanie Rae2, Storrø, Ola2, Johnsen, Roar2, Videm, Vibeke1,3, Øien, Torbjørn2 |
| المصدر: |
Pediatric Allergy & Immunology. Nov2014, Vol. 25 Issue 7, p691-698. 8p. |
| مصطلحات موضوعية: |
*ALLERGENS, *SKIN inflammation, *IMMUNOGLOBULIN E, *CLINICAL trials, *ECZEMA, *ASTHMA |
| مستخلص: |
Background Sensitization toward allergens, as determined by skin prick test ( SPT) or specific Ig E (s Ig E), is a predictor for the later presence of allergy-related disease (atopic eczema, allergic rhinoconjuctivitis and asthma). However, it is not known whether SPT or s Ig E should be the preferred test. The aim of this study was to compare the predictive ability of SPT and s Ig E when performed in a general population of 2-yr-old children. Methods In a prospective, longitudinal population-based study of children aged 2-6 yr, SPT and s Ig E for nine common allergens were performed at 2 yr. Allergy-related disease was evaluated by clinical examination and questionnaire at 2 and 6 yr of age (n = 199). Results Skin prick test or s Ig E was positive in 10.6% and 21.1% in the 2-yr-old children, respectively. The prevalence of allergy-related disease was 25.6% at 2 yr and 25.1% at 6 yr. Half of the cases at 2 yr were transient. Both SPT and s Ig E were statistically significant predictors for later allergy-related disease, OR = 6.5 (95% CI 2.3-18.6) and OR = 4.1 (95% CI 1.9-9.0), respectively. Receiver operating characteristic analysis showed that SPT and s Ig E had comparable predictive ability for atopic eczema, asthma or any allergy-related disease, but s Ig E had better ability to predict later allergic rhinoconjunctivitis. Conclusion Sensitization at 2 yr may be useful predictors of allergy-related disease later in childhood. The predictive ability of SPT and s Ig E were mainly comparable; however, it may be that s Ig E is the preferred choice in young children when the aim is to predict allergic rhinoconjunctivitis. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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