المؤلفون: Tillard, Célia, Cisterne, Camille, Moyart, Marie, Thumerelle, Caroline, Drumez, Elodie, Behal, Hélène, Lejeune, Stéphanie, Deschildre, Antoine

المصدر: Pediatric Allergy & Immunology; Mar2024, Vol. 35 Issue 3, p1-3, 3p

مصطلحات موضوعية: WHEEZE, PULMONOLOGISTS, INHALATION injuries, ASTHMA in children

مستخلص: A pilot study was conducted to assess the inhalation technique in asthmatic children using video clips recorded at home. The study found that in about 82% of cases, the video clips were of sufficient quality to assess the technique. Additionally, the study identified errors in inhalation technique in two-thirds of the children, which could potentially hinder the effectiveness of treatment. The use of home video assessment could be a valuable tool in remotely correcting and improving inhalation technique without waiting for a scheduled visit. Further research is needed to evaluate this method in different care settings and with different devices. [Extracted from the article]

: Copyright of Pediatric Allergy & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Lejeune, Stéphanie, Pichavant, Muriel, Engelmann, Ilka, Béghin, Laurent, Drumez, Elodie, Le Rouzic, Olivier, Dessein, Rodrigue, Rogeau, Stéphanie, Beke, Timothée, Kervoaze, Gwenola, Delvart, Céline, Ducoin, Héloïse, Pouessel, Guillaume, Le Mée, Armelle, Boileau, Sophie, Roussel, Juliette, Bonnel, Cécile, Mordacq, Clémence, Thumerelle, Caroline, Gosset, Philippe

المصدر: Pediatric Allergy & Immunology; Aug2020, Vol. 31 Issue 6, p651-661, 11p

مصطلحات موضوعية: WHEEZE, ASTHMATICS, PRESCHOOL children, CIGARETTE smoke, SPUTUM

مستخلص: Background: Preschool asthma/recurrent wheeze is a heterogeneous condition. Different clinical phenotypes have been described, including episodic viral wheeze (EVW), severe intermittent wheeze (SIW), and multiple‐trigger wheeze (MTW). Objective: To compare clinical, viral, and inflammatory/immune profiling at exacerbation between MTW, SIW, and EVW phenotypes. Methods: Multicenter, prospective, observational cohort (VIRASTHMA‐2). Children (1‐5 years) with preschool asthma were enrolled during hospitalization for a severe exacerbation. History and anamnestic data, plasma, and nasal samples were collected at exacerbation (T1) and at steady state, 8 weeks later (T2), and sputum samples were collected at T1. Results: A total of 147 children were enrolled, 37 (25%) had SIW, 18 (12.2%) EVW, and 92 (63%) MTW. They were atopic (47%), exposed to mold (22%) and cigarette smoke (50%), and prone to exacerbations (≥2 in the previous year in 70%). At exacerbation, at least one virus was isolated in 94% and rhinovirus in 75%, with no difference between phenotypes. Children with MTW and SIW phenotypes displayed lower plasma concentrations of IFN‐γ (P =.002), IL‐5 (P =.020), TNF‐α (P =.038), IL‐10 (P =.002), IFN‐β (P =.036), and CXCL10 (P =.006) and lower levels of IFN‐γ (P =.047) in sputum at exacerbation than children with EVW. At T2, they also displayed lower plasma levels of IFN‐γ (P =.045) and CXCL10 (P =.013). Conclusion: Among preschool asthmatic children, MTW and SIW, prone to exacerbations, display lower systemic levels of Th1, Th2 cytokines, pro‐ and anti‐inflammatory cytokines, and antiviral responses during severe virus‐induced exacerbation. [ABSTRACT FROM AUTHOR]

: Copyright of Pediatric Allergy & Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)