Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population
| العنوان: | Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population |
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| المؤلفون: | Monika Pawałowska, Margarita Lianeri, Paweł P. Jagodziński, Piotr Pawlik, Adrianna Mostowska, Stefan Sajdak, Janina Markowska |
| المصدر: | Pathology Oncology Research |
| بيانات النشر: | Springer Netherlands, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Oncology, Adult, medicine.medical_specialty, Cancer Research, Genotype, Genome-wide association study, Single-nucleotide polymorphism, Nucleoside Transport Proteins, Carcinoma, Ovarian Epithelial, Bioinformatics, Genome-wide association studies, Polymorphism, Single Nucleotide, Pathology and Forensic Medicine, Ovarian cancer, Risk Factors, Ovarian carcinoma, Internal medicine, Medicine, SNP, Humans, Genetic Predisposition to Disease, Neoplasms, Glandular and Epithelial, Genetic association, Homeodomain Proteins, Ovarian Neoplasms, business.industry, Research, Cancer, General Medicine, Single nucleotide polymorphisms, Middle Aged, medicine.disease, Endonucleases, Phosphoproteins, Serous fluid, Genetic Loci, Case-Control Studies, Female, Poland, Poly(ADP-ribose) Polymerases, business, Genome-Wide Association Study |
| الوصف: | We investigated the previously-demonstrated association of seven genome-wide association studies (GWAS) single nucleotide polymorphisms (SNPs), including rs2072590 (HOXD-AS1), rs2665390 (TIPARP), rs10088218 and rs10098821 (8q24), rs3814113 (9p22), rs9303542 (SKAP1) and rs2363956 (ANKLE1), as risk factors of epithelial ovarian tumors (EOTs). These SNPs were genotyped in two hundred seventy three patients with EOTs and four hundred sixty four unrelated healthy females from the Polish population. We observed the lowest p values of the trend test for the 9p22 rs3814113 and 8q24 rs10098821 SNPs in patients with all subtypes of ovarian cancer (ptrend = 0.010 and ptrend = 0.014, respectively). There were also significant p values for the trend of the 9p22 rs3814113 and the 8q24 rs10098821 SNPs for serous histological subtypes of ovarian cancer (ptrend = 0.006, ptrend = 0.033, respectively). Moreover, stratification of the patients based on their histological type of cancer demonstrated, in the dominant hereditary model, a significant association of the 9p22 rs3814113 SNP with serous ovarian carcinoma OR = 0.532 (95 % CI = 0.342 - 0.827, p = 0.005, pcorr = 0.035). Despite the relatively small sample size of cases and controls, our studies confirmed some of the previously-demonstrated GWAS SNPs as genetic risk factors for EOTs. Electronic supplementary material The online version of this article (doi:10.1007/s12253-014-9822-6) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| تدمد: | 1532-2807 1219-4956 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb2b2589cb6c218b859400d9de48f7cTest http://europepmc.org/articles/PMC4422849Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3bb2b2589cb6c218b859400d9de48f7c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15322807 12194956 |
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