التفاصيل البيبلوغرافية
| العنوان: |
Primary intramucosal synovial sarcoma of the sigmoid colon in a patient with a germline mutation in the MSH2 gene: A case report. |
| المؤلفون: |
Shigematsu, Yasuyuki, Yamashita, Kyoko, Takamatsu, Manabu, Tanizawa, Taisuke, Togashi, Yuki, Nakajima, Takeshi, Chino, Akiko, Kawachi, Hiroshi, Takeuchi, Kengo |
| المصدر: |
Pathology International; Dec2020, Vol. 70 Issue 12, p1015-1019, 5p |
| مصطلحات موضوعية: |
SYNOVIOMA, SIGMOID colon, DNA mismatch repair, GENETIC mutation, SARCOMA, ENDOSCOPIC surgery |
| مستخلص: |
Synovial sarcoma is a high‐grade soft tissue sarcoma that occurs primarily in the deep soft tissue of extremities, and primary colorectal synovial sarcoma is extremely rare. In this report, we present a synovial sarcoma mostly located within the mucosa of the sigmoid colon. The patient was a man in his forties with a germline deletion in the MSH2 gene. He had experienced undifferentiated pleomorphic sarcoma of the left forearm 7 years before and adenocarcinoma of the transverse colon 6 years before, both of which were successfully treated and exhibited no recurrence to date. A surveillance colonoscopy for Lynch syndrome revealed the tumor which had a submucosal tumor‐like appearance with central erosion and endoscopic resection was performed. Histologically, it was composed of monotonous proliferation of spindle cells arranged in cellular fascicles; these findings were compatible with monophasic fibrous synovial sarcoma. In the tumor cells, the presence of the SS18‐SSX1 fusion gene was confirmed. Protein expression of mismatch repair genes was intact in the tumor cells, indicating the association between microsatellite instability and synovial sarcoma was weak. The present case highlights a rare primary site of synovial sarcoma in a patient with Lynch syndrome. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pathology International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
