التفاصيل البيبلوغرافية
| العنوان: |
Molecular pathways of programmed cell death in experimental Parkinson's disease. |
| المؤلفون: |
Vila M (AUTHOR), Perier C (AUTHOR), Vila, Miquel1 (AUTHOR), Perier, Celine (AUTHOR) |
| المصدر: |
Parkinsonism & Related Disorders. Jan2008, Vol. 14 Issue 1, pS176-9. 1p. |
| مستخلص: |
Dysfunction of mitochondrial complex I leads to degeneration of dopaminergic neurons of the substantia nigra pars compacta, as seen in Parkinson's disease, through activation of mitochondria-dependent programmed cell death pathways. In this scenario, complex I blockade increases the soluble pool of cytochrome c in the mitochondrial intermembrane space through oxidative mechanisms, whereas activation of pro-cell death protein Bax triggers neuronal death by permeabilizing the outer mitochondrial membrane and releasing cytochrome c into the cytosol. Targeting either Bax transcriptional or post-translational activation results in a marked attenuation of dopaminergic cell death caused by complex I inhibition. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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