Ultrastructural analysis of edelfosine-treated trypomastigotes and amastigotes of Trypanosoma cruzi
| العنوان: | Ultrastructural analysis of edelfosine-treated trypomastigotes and amastigotes of Trypanosoma cruzi |
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| المؤلفون: | Helene Santos Barbosa, R. M. Santa-Rita, S. L. De Castro |
| المصدر: | Parasitology Research. 100:187-190 |
| بيانات النشر: | Springer Science and Business Media LLC, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Chagas disease, Phosphodiesterase Inhibitors, Trypanosoma cruzi, Mitochondrion, chemistry.chemical_compound, parasitic diseases, Organelle, medicine, Animals, Humans, Chagas Disease, Amastigote, Miltefosine, General Veterinary, biology, Phospholipid Ethers, Kinetoplastida, General Medicine, biology.organism_classification, medicine.disease, Microscopy, Electron, Infectious Diseases, Biochemistry, chemistry, Insect Science, Parasitology, Edelfosine, medicine.drug |
| الوصف: | We have previously reported that epimastigote forms of Trypanosoma cruzi treated with the lysophospholipid analogues (LPAs) edelfosine (ET-18), ilmofosine, and miltefosine suffered alterations in plasma membrane, mitochondrion, and lipid synthesis. In this work, ET-18 induced membrane damage in trypomastigotes and amastigotes. Incubation of epimastigotes and trypomastigotes with the three LPAs led to membrane permeabilization, which was abolished by serum addition. Treatment for 24 h in culture medium interfered the with mitochondrial status of epimastigotes, with no effect in trypomastigotes, in agreement with ultrastructural data. LPAs induced alterations in the plasma membrane of the three forms of T. cruzi and in the mitochondria of epimastigotes, suggesting that these organelles are potential targets of these analogues. |
| تدمد: | 1432-1955 0932-0113 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e19d7751757bc14614955d661069ce3Test https://doi.org/10.1007/s00436-006-0250-8Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....9e19d7751757bc14614955d661069ce3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321955 09320113 |
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