Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection
| العنوان: | Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection |
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| المؤلفون: | Malcolm K. Jones, Carolina De Marco Verissimo, Kieran V. Aland, Donald P. McManus, Helen Owen, Simon Reid, Rebecca J. Traub, Mahdis Aghazadeh, James S. McCarthy, Marina Harvie |
| المصدر: | Parasitology. 143:1243-1251 |
| بيانات النشر: | Cambridge University Press (CUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Eosinophilic Meningitis, Angiostrongylus vasorum, T-Lymphocytes, Guinea Pigs, 030231 tropical medicine, Spleen, Interferon-gamma, Mice, 03 medical and health sciences, 0302 clinical medicine, Eosinophilia, medicine, Animals, Humans, Meningitis, Angiostrongylus, Strongylida Infections, biology, Angiostrongylus cantonensis, Brain, Meningoencephalitis, 030108 mycology & parasitology, biology.organism_classification, medicine.disease, Virology, Disease Models, Animal, Infectious Diseases, medicine.anatomical_structure, Antigens, Helminth, Angiostrongyliasis, Cytokines, Female, Animal Science and Zoology, Parasitology |
| الوصف: | SUMMARYThis study investigated comparatively the pathogenicity of experimental infection of mice and guinea pigs, with Angiostrongylus mackerrasae and the closely related species A. cantonensis. Time course analyses showed that A. mackerrasae causes eosinophilic meningitis in these hosts, which suggests that the species has the potential to cause meningitis in humans and domestic animals. Both A. mackerrasae and the genetically similar A. cantonensis caused eosinophilic meningitis in mice at two time points of 14 and 21 days post infection (dpi). The brain lesions in mice infected with A. mackerrasae were more granulomatous in nature and the parasites were more likely to appear degenerate compared with lesions caused by A. cantonensis. This may indicate that the mouse immune system eliminates A. mackerrasae infection more effectively. The immunologic responses of mice infected with the two Angiostrongylus species was compared by assessing ex vivo stimulated spleen derived T cells and cytokines including interferon-gamma, interleukin 4 and interleukin 17 on 14 and 21 dpi. The results were similar for mice infected with A. cantonensis and A. mackerrasae. Serum from the infected animals with either A. cantonensis or A. mackerrasae recognized total soluble antigen of A. cantonensis female worms on Western blot. |
| تدمد: | 1469-8161 0031-1820 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c06403ddc13641286948270fd4eb818Test https://doi.org/10.1017/s003118201600069xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6c06403ddc13641286948270fd4eb818 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698161 00311820 |
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