التفاصيل البيبلوغرافية
| العنوان: |
Botulinum Type A Toxin Complex for the Relief of Upper Back Myofascial Pain Syndrome: How Do Fixed-Location Injections Compare with Trigger Point-Focused Injections? |
| المؤلفون: |
Benecke, Reiner1, Heinze, Axel2, Reichel, Gerhard3, Hefter, Harald4, Göbel, Hartmut2 |
| المصدر: |
Pain Medicine. Nov2011, Vol. 12 Issue 11, p1607-1614. 8p. 2 Diagrams, 2 Charts, 4 Graphs. |
| مصطلحات موضوعية: |
*TREATMENT of backaches, *THERAPEUTICS, *MYOFASCIAL pain syndrome treatment, *ANALYSIS of variance, *BLOOD pressure measurement, *BODY weight, *BOTULINUM toxin, *INJECTIONS, *LONGITUDINAL method, *EVALUATION of medical care, *MEDICAL needs assessment, *MEDICAL cooperation, *MYOFASCIAL pain syndromes, *PAIN, *RESEARCH, *SAFETY, *STATISTICS, *STATURE, *U-statistics, *DATA analysis, *HUMAN research subjects, *PATIENT selection |
| مستخلص: |
Objective. This was a prospective, randomized, double-blind, placebo-controlled, 12-week, multicenter study to evaluate the efficacy and tolerability of fixed location injections of botulinum type A toxin (BoNT-A, Dysport) in predetermined injection sites in patients with myofascial pain syndrome of the upper back. Design. Patients with moderate-to-severe myofascial pain syndrome affecting cervical and/or shoulder muscles (10 trigger points, disease duration 6-24 months) and moderate-to-severe pain intensity were randomized to BoNT-A (N = 81) or saline (N = 72). Intervention. Patients received treatment into 10 predetermined fixed injection sites in the head, neck, and shoulder (40 units of BoNT-A per site or saline, a total of 400 units of BoNT-A). Outcome Measures. The primary efficacy outcome was the proportion of patients with mild or no pain at week 5 (responders). Secondary outcomes included changes in pain intensity and the number of pain-free days per week. Results. At week 5, 49% (37/76) of BoNT-A patients and 38% (27/72) of placebo patients had responded to treatment ( P = 0.1873). Duration of daily pain was reduced in the BoNT-A group compared with the placebo group from week 5, with statistically significant differences at weeks 9 and 10 ( P = 0.04 for both). Treatment was well tolerated. Conclusion. Fixed-location treatment with BoNT-A of patients with upper back myofascial pain syndrome did not lead to a significant improvement of the main target parameter in week 5 after treatment. Only in week 8 were significant differences found. Several secondary parameters, such as physicians' global assessment and patients' global assessment, significantly favored BoNT-A over placebo at weeks 8 and 12. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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