Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload
| العنوان: | Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload |
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| المؤلفون: | Roman Kotlín, Jan E. Dyr, Jiří Suttnar, Kristýna Pimková, Leona Chrastinova, Jana Štikarová, Jaroslav Cermak |
| المصدر: | Oxidative Medicine and Cellular Longevity, Vol 2014 (2014) Oxidative Medicine and Cellular Longevity |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Aging, medicine.medical_specialty, Iron Overload, Homocysteine, Article Subject, Iron, Context (language use), medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Internal medicine, Malondialdehyde, medicine, Humans, Sulfhydryl Compounds, Nitrite, lcsh:QH573-671, Nitrites, Nitrates, medicine.diagnostic_test, lcsh:Cytology, Myelodysplastic syndromes, Cell Biology, General Medicine, Glutathione, Dipeptides, medicine.disease, Oxidative Stress, Endocrinology, Treatment Outcome, chemistry, Case-Control Studies, Myelodysplastic Syndromes, Ferritins, Serum iron, Oxidation-Reduction, Oxidative stress, Research Article |
| الوصف: | The role of oxidative stress in the initiation and progression of myelodysplastic syndromes (MDS) as a consequence of iron overload remains unclear. In this study we have simultaneously quantified plasma low-molecular-weight aminothiols, malondialdehyde, nitrite, and nitrate and have studied their correlation with serum iron/ferritin levels, patient treatment (chelation therapy), and clinical outcomes. We found significantly elevated plasma levels of total, oxidized, and reduced forms of cysteineP<0.001, homocysteineP<0.001, and cysteinylglycineP<0.006and significantly depressed levels of total and oxidized forms of glutathioneP<0.03and nitriteP<0.001in MDS patients compared to healthy donors. Moreover, total(P=0.032)and oxidized cysteinylglycine(P=0.029)and nitrite(P=0.021)differed significantly between the analyzed MDS subgroups with different clinical classifications. Malondialdehyde levels in plasma correlated moderately with both serum ferritin levels(r=0.78, P=0.001)and serum free iron levels(r=0.60, P=0.001)and were significantly higher in patients with iron overload. The other analyzed compounds lacked correlation with iron overload (represented by serum iron/ferritin levels). For the first time our results have revealed significant differences in the concentrations of plasma aminothiols in MDS patients, when compared to healthy donors. We found no correlation of these parameters with iron overload and suggest the role of oxidative stress in the development of MDS disease. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1942-0994 1942-0900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa799daacd2b0d7a0bad7798088fa845Test https://doaj.org/article/2ce2c525f3114a3381615338992dd79fTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fa799daacd2b0d7a0bad7798088fa845 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
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