Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms
| العنوان: | Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms |
|---|---|
| المؤلفون: | Tannaz Jamialahmadi, Habib Yaribeygi, Amirhossein Sahebkar, Mina Maleki, Thozhukat Sathyapalan |
| المصدر: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Aging, Incretin, 030209 endocrinology & metabolism, Review Article, Pharmacology, medicine.disease_cause, Incretins, Biochemistry, Antioxidants, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Dipeptidyl-Peptidase IV Inhibitors, QH573-671, business.industry, Therapeutic effect, Cell Biology, General Medicine, medicine.disease, 030104 developmental biology, Diabetes Mellitus, Type 2, Metabolic effects, Cytology, business, Oxidative stress, Hormone |
| الوصف: | Glucagon-like peptide 1 receptor agonists and dipeptidyl-peptidase 4 inhibitors are medications used for managing diabetes, mimicking the metabolic effects of incretin hormones. Recent evidence suggests that these medications have antioxidative potentials in the diabetic milieu. The pathophysiology of most diabetic complications involves oxidative stress. Therefore, if incretin-based antidiabetic medications can alleviate the free radicals involved in oxidative stress, they can potentially provide further therapeutic effects against diabetic complications. However, the molecular mechanisms by which these medications protect against oxidative stress are not fully understood. In the current review, we discuss the potential molecular mechanisms behind these pharmacologic agents’ antioxidative properties. |
| تدمد: | 1942-0994 1942-0900 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fba53a080b46cfb480cfd58a8977bbfTest https://doi.org/10.1155/2021/9959320Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8fba53a080b46cfb480cfd58a8977bbf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19420994 19420900 |
|---|