Stereospecific Synthesis of Tetrahydronaphtho[2,3-b]furans Enabled by a Nickel-Promoted Tandem Reductive Cyclization
| العنوان: | Stereospecific Synthesis of Tetrahydronaphtho[2,3-b]furans Enabled by a Nickel-Promoted Tandem Reductive Cyclization |
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| المؤلفون: | Shu-Ming Duan, Li Ren, Ya-Wen Wang, Yu Peng, Xiao-Bo Xu, Jian Xiao, Yong-Liang Shao |
| المصدر: | Organic Letters. 18:5170-5173 |
| بيانات النشر: | American Chemical Society (ACS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Tandem, 010405 organic chemistry, Organic Chemistry, chemistry.chemical_element, Substrate (chemistry), 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Nickel, Stereospecificity, chemistry, Organic chemistry, Stereoselectivity, Physical and Theoretical Chemistry |
| الوصف: | A Ni-mediated cascade to a stereoselective synthesis of trans-tetrahydronaphtho[2,3-b]furans is efficiently achieved for the first time. The mild reductive system can be easily generated from inexpensive and air-stable materials and shows a broad positional tolerance of substituents that were previously difficult or impossible to access by other methods. Facile syntheses toward new analogues of therapeutic agents (iso)deoxypodophyllotoxin are also reported. In addition, the inherent substrate control is disclosed for the observed unique stereoselectivities during cyclizations. |
| تدمد: | 1523-7052 1523-7060 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0370174b5996764b2b5edb7c65083494Test https://doi.org/10.1021/acs.orglett.6b02665Test |
| رقم الانضمام: | edsair.doi.dedup.....0370174b5996764b2b5edb7c65083494 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15237052 15237060 |
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