التفاصيل البيبلوغرافية
| العنوان: |
T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction. |
| المؤلفون: |
Mutlu, N, Erdal, ME, Herken, H, Oz, G, Bayazıt, YA |
| المصدر: |
Oral Diseases; Nov2004, Vol. 10 Issue 6, p349-352, 4p |
| مصطلحات موضوعية: |
TEMPOROMANDIBULAR disorders, SEROTONIN, TRYPTAMINE, NEUROTRANSMITTERS, POLYMERASE chain reaction, FACIAL pain |
| مستخلص: |
To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction.Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique.The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05).The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
