المؤلفون: A Palmieri, A Tagliabue, M Nardone, L Tettamanti, Anna Avantaggiato

المساهمون: Tettamanti, L., Avantaggiato, A., Nardone, M., Palmieri, A., Tagliabue, Angelo

المصدر: Oral & Implantology. 10:11

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Candidate gene, Folic acid, Locus (genetics), Congenital craniofacial anomaly, Gene, 03 medical and health sciences, Gene mapping, Smoke, Epidemiology, medicine, Original Research Article, Alcohol, Cleft, Linkage, Methylenetetrahydrofolate reductase, Dentistry (all), General Dentistry, Genetics, biology, stomatognathic diseases, 030104 developmental biology, Etiology, biology.protein

الوصف: Cleft of the lip and/or palate (CL±P) is the most common congenital craniofacial anomaly affecting around 1 in 700 live births worldwide. Clefts of the human face can be classified anatomically as cleft lip only (CL), cleft palate only (CP), cleft lip and palate (CLP) or a combined group of cleft lip with or without cleft palate (CL±P), based on differences in embryologic development. CL±P has a genetic base and several linkage and association analyses have been performed in order to obtain important information about the role of candidate genes in its onset; not less important are gene-environment interactions that play an increasing role in its aetiology. In CL±P, several loci have been seen associated with the malformation, and, in some cases, a specific gene mapping in a locus has also been identified as susceptibility factor. In CP, one gene has been found, but many more are probably involved. In this short review the genetic studies carried out on CL±P, and the interaction with environmental factors (alcohol, smoking, drugs) are discussed.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f7984370d214cff03be987ca8763ecTest
https://doi.org/10.11138/orl/2017.10.1.011Test

المؤلفون: Claudio Arcuri, Liliana Ottria, D. Testi, M Nardone, P Cardelli, P Melone

المصدر: Oral & Implantology.

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Focal Epithelial Hyperplasia, virus diseases, Review, Condyloma Acuminatum, medicine.disease, Dermatology, female genital diseases and pregnancy complications, Virus, Vaccination, Oral sex, Settore MED/28 - Malattie Odontostomatologiche, medicine, Squamous cell papilloma, Sex organ, business, General Dentistry, Verruca Vulgaris

الوصف: The importance of HPV in world healthy is high, in fact high-risk HPV types contribute significantly to viral associated neoplasms. In this article we will analyze vary expression of HPV in oral cavity both benign and malignant, their prevalence and the importance in early diagnosis and prevention. The classical oral lesions associated with human papillomavirus are squamous cell papilloma, condyloma acuminatum, verruca vulgaris and focal epithelial hyperplasia. Overall, HPV types 2, 4, 6, 11, 13 and 32 have been associated with benign oral lesions while HPV types 16 and 18 have been associated with malignant lesions, especially in cancers of the tonsils and elsewhere in the oropharynx. Transmission of the virus can occur with direct contact, genital contact, anal and oral sex; latest studies suggest a salivary transmission and from mother to child during delivery. The number of lifetime sexual partners is an important risk factor for the development of HPV-positive head-neck cancer. Oral/oropharyngeal cancer etiologically associated with HPV having an increased survival and a better prognostic (85%-90% to five years). There is no cure for the virus. There are two commercially available prophylactic vaccines against HPV today: the bivalent (16 and 18) Cervarix® and the tetravalent (6, 11, 16 and 18) Gardasil® and new vaccine Gardasil 9 (6, 11, 16, 18, 31, 33, 45, 52, 58) was approved in the United States. To be effective, such vaccination should start before "sexual puberty". The vaccine could be an important preventive strategy, in fact the scientific community is in agreement on hypothesis that blocking the contagion it may also limit the distance complications as the oropharyngeal cancer.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fc152130a01a49e9cd7e8ea86e3b2bTest
https://doi.org/10.11138/orl/2015.8.2.045Test

المؤلفون: Angelo Tagliabue, M Nardone, Lucia Tettamanti, Javier Silvestre-Rangil, Anna Avantaggiato

المصدر: Oral & Implantology. 10:45

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Weakness, Complex disease, Prenatal diagnosis, Disease, Congenital, 03 medical and health sciences, 0302 clinical medicine, medicine, Genetic epidemiology, Original Research Article, 030223 otorhinolaryngology, Aerophagia, General Dentistry, Birth defects, Cleft palate, Cleft palate only, Dentistry (all), Pregnancy, business.industry, medicine.disease, Penetrance, 030220 oncology & carcinogenesis, Unintelligible speech, medicine.symptom, business

الوصف: Cleft palate only (CPO) is one of the most common congenital malformations worldwide. The etiopathogenesis of CPO is not completely understood. Environmental factors, such as smoking, alcohol consumption, intake of drugs during pregnancy, advanced paternal age, have been demonstrated to be a risk of CPO, but conflicting results have also been published. Insufficient intake of folic acid during the pregnancy has been suggested to increase the risk for CPO. The demonstrated risk for siblings and the higher risk for monozygotic twins suggest a genetic etiopathogenesis for CPO. In some cases of CPO a prevalent mode of inheritance has been reported, but oligogenic models with reduced penetrance, and the risk related to environmental factors have also been proved. One of the first manifestations associated with CPO is difficulty with feeding. Aerophagia is a problem in these infants with CPO and requires more frequent burping and slower feeding. The inability to generate intraoral breath pressure due to nasal air emission in CPO children frequently manifests as articulation difficulties, particularly consonant weakness, and unintelligible speech. Hearing disorders are prevalent among individuals with CPO, as a result of chronic otitis media with effusion due to eustachian tube dysfunction. A multidisciplinary team is essential to manage the many aspects of CPO. In treating CPO, the reconstructive surgeon works in cooperation with otolaryngologists, dentists and orthodontists, speech pathologists, audiologists, geneticists, psychiatrists, maxillofacial surgeons, social workers, and prosthodontists. CPO can be considered a genetically complex disease, but new knowledge and new therapeutic approaches have greatly improved the quality of life of these children. Prenatal diagnosis is an important step in the treatment of this disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac83a6c1606bb10ce1cdcf0d0098e38Test
https://doi.org/10.11138/orl/2017.10.1.045Test

المؤلفون: CANDOTTO, V., GARGARI, M., GAUDIO, R. M., CURA, F., BAGGI, L., ARCURI, C., GATTO, R., NARDONE, M., SPADARI, F., CARINCI, F.

المصدر: ORAL & Implantology; Jan-Mar2018, Vol. 11 Issue 1, p72-76, 5p

مصطلحات موضوعية: HEAD & neck cancer treatment, PAPILLOMAVIRUS diseases, HEAD & neck cancer diagnosis

مستخلص: Human papillomavirus (HPV) is responsible for a growing subset of oropharyngeal squamous cell carcinomas (OPSCCs) in the United States and abroad. At the time of the primary diagnosis, HPV-positive tumor status is associated with improved response to chemo-radiation, progression-free survival, and overall survival. Patients with HPV-related cancer look very different than the prototypic patient with tobacco-related SCC of the oral cavity. They tend to be white males that are younger, of higher socioeconomic status, and more highly educated. Moreover, they are often non-smokers who do not abuse alcohol. HPV-related SCC has a strong predilection for the oropharynx, particularly the lingual and palatine tonsils. HPV-16 genotype is the most common genotype, accounting for up to 92% of HPV-positive oropharyngeal squamous cell carcinomas. The need for routine HPV testing of oropharyngeal carcinomas is urgent and compelling. First, HPV status is a powerful indicator of patient prognosis. HPV positivity correlates with a lower risk of tumor progression and death, reflecting in part an enhanced sensitivity to ionizing radiation with or without chemotherapy. In our understanding, HPV status, which is easily acquired with routine investigations, should be included in the standard operational procedures for the diagnosis and treatment of head and neck cancer patients. [ABSTRACT FROM AUTHOR]

: Copyright of ORAL & Implantology is the property of CIC Edizioni Internazionali s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: LOMBARDO, L., VERONESI, F., CANDOTTO, V., NARDONE, M., SICILIANI, G.

المصدر: ORAL & Implantology; Oct-Dec2017, Vol. 10 Issue 4, p424-438, 15p

مصطلحات موضوعية: DENTAL arch, CONE beam computed tomography, CEPHALOMETRY

مستخلص: Purpose. To determine the existence of any correlation between the degree of divergence and apical and coronal arch form using cone-beam computed tomography (CBCT). Materials and methods. A total of 176 (88 coronal and 88 apical) CBCT scans pertaining to a sample of 44 subjects (16 males and 28 females), of which 26 were Class I, 14 Class II and 4 Class III, were analysed. A lateral projection of the skull was obtained from each VCT and cephalometric tracing was performed (according to Ricketts) so as to divide the sample into subgroups based on the degree of divergence (11 short-faced, 18 norm-faced and 15 long-faced subjects). Dahlberg's index values were calculated and Student's t-test for paired data was applied. Results. On the whole, the hyperbolic cosine curve was found to be the most representative of the arch forms considered. Conclusions. A correlation between degree of divergence and the arch form of the apical and, especially, coronal portions of both the upper and lower jaws was revealed. [ABSTRACT FROM AUTHOR]

: Copyright of ORAL & Implantology is the property of CIC Edizioni Internazionali s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Marco E Pasqualini, F Meynardi, Michele Nardone, L Dal Carlo, L Baggi, Filippo Rossi

المصدر: Oral & Implantology. 9:10

مصطلحات موضوعية: healing screw, Implant dentistry, business.industry, absence of functional load, transmucosal peri-implant path, Dentistry, bacterial morphological profile, two-piece implant, 030206 dentistry, Settore MED/28, Osseointegration, 03 medical and health sciences, 0302 clinical medicine, Surgical site, Medicine, Original Research Article, Implant, business, General Dentistry, 030215 immunology

الوصف: Purpose To assess the changes in bacterial profile along the transmucosal path of healing screws placed immediately after insertion of two-piece endosseus implants during the 4-month osseointegration phase, in absence of functional load. Materials and methods Two site-specific samples were collected at the peri-implant mucosa of the healing screws of 80 two-piece implants, for a total of 640 samples. Implants placement was performed following a single protocol with flapless technique, in order to limit bacterial contamination of the surgical site. Identical healing screws (5 mm diameter/4 mm height) were used for each of the 80 implants. During the 4 months of the study, the patients followed a standard oral care regimen with no special hygiene maneuvers at the collection sites. Results The present research documents that during the 4-month period prior to application of function load the bacterial profile of all sites exhibited a clear prevalence of cocci at the interface between implant neck and osteoalveolar crest margin. Conclusions A potentially pathogenic bacterial flora developed only along the peri-implant transmucosal path.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406ccc2cd7e594b5ec7137e35b12ac0fTest
https://doi.org/10.11138/orl/2016.9.1s.010Test

المؤلفون: LAURITANO, D.¹, NARDONE, M.², GAUDIO, R. M.³, CANDOTTO, V.⁴, CARINCI, F.⁴ crc@unife.it

المصدر: ORAL & Implantology. Jul-Sep2017, Vol. 10 Issue 3, p283-288. 6p.

مصطلحات موضوعية: *HEALTH risk assessment, *LEGIONELLA pneumophila, *GRAM-negative aerobic bacteria

مستخلص: The aerosol produced during the use of dental instruments can spread pathogens potentially harmful to health. Most of the pathogens found in hydraulic system are Gram-negative aerobic heterotrophic environmental bacterial species exhibiting very low pathogenicity, although they may be of concern in the treatment of vulnerable patients, such as immunocompromised, medically compromised individuals and dental team. Dental team can be exposed to pathogenic microorganisms including cytomegalovirus, hepatitis B virus, hepatitis C virus, herpes simplex virus and Legionella spp. Legionella spp. are ubiquitous in hydraulic system, in fact surveys have shown that the percentage of samples taken at different dental chairs that were positive for Legionella spp. and ranged from 0 to 100%. The concentration of Legionella spp. in hydraulic system may reach 1000 organisms per ml. The primary route of Legionella spp. transmission is inhalation or aspiration of environmentally contaminated aerosols. All dentists are required to conduct a statutory risk assessment of their hydraulic system, in fact to comply with their legal duties, dentists must identify and assess the sources of risk and prepare a scheme for preventing and controlling risks. Moreover, they must monitor the quality of their hydraulic system at least annually to ensure that they are "legionellae free". [ABSTRACT FROM AUTHOR]

المؤلفون: LAURITANO, D., SBORDONE, L., NARDONE, M., IAPICHINO, A., SCAPOLI, L., CARINCI, F.

المصدر: ORAL & Implantology; Jul-Sep2017, Vol. 10 Issue 3, p229-233, 5p

مصطلحات موضوعية: PERIODONTAL disease, COLON cancer, ORAL microbiology

مستخلص: Diagnosis of focal disease, the theory that the human oral microbial (HOM) could affect the onset and development of systemic diseases, was very popular in the past, but the lack of scientific evidence has led to the abandonment of this idea. Interestingly, increasing evidence over the past 3 or so decades suggests that HOM can indeed serve as a reservoir for systemic dissemination of pathogenic bacteria and their toxins in distant body sites, favouring the developments of malignant tumours. Malignant tumours are complex communities of oncogenically transformed cells with aberrant genomes, associated nonneoplastic cells including immune and stromal cells, and sometimes HOM, including bacteria and viruses. Recent data suggest that HOM and periodontal disease play an active role in the pathogenesis of colorectal cancer, in fact HOM has been found within the colorectal cancer microenvironment, and the composition of the HOM was different from that of adjacent non- neoplastic tissue. An association of fusobacterium nucleatum with the colonic mucosa of colorectal cancer has been proven. Several questions thus arise. Is periodontal disease a risk factor for colorectal carcinoma? Given the connectivity of the digestive tract, could fusubacterium nucleatum or other HOM be involved in additional gastrointestinal disorders? Furthermore, based on the ''mobility'' of Fusubacterium nucleatum and the omnipresence of cadherins, could this organism be involved in cancers beyond the gastrointestinal tract? Answers to these questions will shed new lights on the role of the HOM in onset of diseases. [ABSTRACT FROM AUTHOR]

: Copyright of ORAL & Implantology is the property of CIC Edizioni Internazionali s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: CANDOTTO, V., LAURITANO, D., NARDONE, M., BAGGI, L., ARCURI, C., GATTO, R., GAUDIO, R. M., SPADARI, F., CARINCI, F.

المصدر: ORAL & Implantology; Jul-Sep2017, Vol. 10 Issue 3, p209-220, 12p

مصطلحات موضوعية: PAPILLOMAVIRUSES, EPIDEMIOLOGY of sexually transmitted diseases, ORAL cancer

مستخلص: Purpose. The aim of this paper is to describe epidemiology and clinical manifestations of oral infection by Human papillomavirus (HPV), with particular attention to potential malignant lesions. Materials and methods. A systematic review of the literature was conducted to describe the state of the art about HPV infection in oropharyngeal mucosa and its modalities of transmission, with particular attention to possible simultaneous infection in multiple anatomic sites. The aspects of prevention and control of infection by administering vaccines and the diffusion of sexual education campaigns are discussed also. Therapeutic protocols are also described where necessary. Results. In recent years there has been a growing interest in HPV oral medicine, suggesting a role of such a family of viruses in the development of neoplasms of the oropharyngeal district as well as of the uterine cervix. Even if the mass media have increasingly faced the problem, causing frequent alarming among patients, the dentist therefore needs a complete and up-to-date knowledge of this infectious condition that is one of the most common causes of sexually transmitted mucous membrane infections (e.g. genital, anal and oral). Conclusions. Recent studies about HPV infection are a basic requirement in order to promote the health of patients and provide them with the most exhaustive indications from dentists. [ABSTRACT FROM AUTHOR]

: Copyright of ORAL & Implantology is the property of CIC Edizioni Internazionali s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: TETTAMANTI, L., LAURITANO, D., NARDONE, M., GARGARI, M., SILVESTRE-RANGIL, J., GAVOGLIO, P., TAGLIABUE, A.

المصدر: ORAL & Implantology; Apr-Jun2017, Vol. 10 Issue 2, p112-118, 7p

مصطلحات موضوعية: PERIODONTAL disease treatment, PERIODONTAL disease diagnosis, PREGNANCY complications, ORAL microbiology, IMMUNE response

مستخلص: Periodontal disease (PD) is an inflammatory disease of the tissues supporting the teeth. PD affects 65 million adults over the age of 30 years in the USA, and worldwide 5 to 70% of adults. Women who develop PD during pregnancy, it's estimated 1 woman in 5, may have a higher risk of adverse pregnancy outcomes. PD during pregnancy starts by dental plaque and is increased by the action of pregnancy hormones. In order to study the effect of PD on adverse pregnancy outcomes, we have performed this narrative review summarising the current studies about the influence of PD on pregnancy. Periodontal pockets are a reservoir of oral microbiota. Modifications in oral microbiota may be considered as a potential mechanism for developing PD during pregnancy. PD is surely caused by bacteria, but the progression and worsening are due to a host immune response. The inflammation caused by PD is not limited to the oral cavity. It is hypothesized that episodes of bacteraemia and dissemination of endotoxins from periodontal pockets can induce the activation of the systemic immune response. In conclusion our narrative review shows that there's no relationship between PD and adverse pregnancy outcomes, and PD treatment during pregnancy does not confer a general protection against adverse pregnancy outcomes. [ABSTRACT FROM AUTHOR]

: Copyright of ORAL & Implantology is the property of CIC Edizioni Internazionali s.r.l. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)