دورية
Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue
| العنوان: | Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue |
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| المؤلفون: | Krishnaswamy, Venkataramanan, Laughney, Ashley M., Paulsen, Keith D., Pogue, Brian W. |
| المصدر: | Optics Letters; May 2011, Vol. 36 Issue: 10 p1911-1913, 3p |
| مستخلص: | A dark-field geometry spectral imaging system is presented to raster scan thick tissue samples in situ in 1.5?cm square sections, recovering full spectra from each 100?μm diameter pixel. This spot size provides adequate resolution for wide field scanning, while also facilitating scatter imaging without requiring sophisticated light–tissue transport modeling. The system is demonstrated showing accurate estimation of localized scatter parameters and the potential to recover absorption-based contrast from broadband reflectance data measured from 480?nm up to 750?nm in tissue phantoms. Results obtained from xenograft pancreas tumors show the ability to quantitatively image changes in localized scatter response in this fast-imaging geometry. The polychromatic raster scan design allows the rapid scanning necessary for use in surgical/clinical applications where timely decisions are required about tissue pathology. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 01469592 15394794 |
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