Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas
| العنوان: | Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas |
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| المؤلفون: | Caitlin White, M. Sean Grady, Peter Snyder, James N. Palmer, John T. Pierce, Sunil Singhal, MacLean Nasrallah, Nithin D. Adappa, Jun Jeon, John Y K Lee, Steve S. Cho, Ryan Zeh, Jason G. Newman, Philip S. Low, Julia Kharlip |
| المصدر: | Oper Neurosurg (Hagerstown) |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adenoma, Adult, Male, Folate Receptor Alpha, Fluorescence, 030218 nuclear medicine & medical imaging, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Text mining, Pituitary adenoma, Monitoring, Intraoperative, Humans, Medicine, Neoplasm, Folate Receptor 1, Pituitary Neoplasms, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Optical Imaging, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Folate receptor, Immunohistochemistry, Female, Surgery, Technique Assessment, Neurology (clinical), business, Nuclear medicine, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND: Surgical resection is the primary treatment for nonfunctional (NF) pituitary adenomas, but gross-total resection is difficult to achieve in all cases. NF adenomas overexpress folate receptor alpha (FRα). OBJECTIVE: To test the hypothesis that we could target FRα for highly sensitive and specific intraoperative detection of NF adenomas using near-infrared (NIR) imaging. METHODS: Fourteen patients with NF pituitary adenoma were infused with the folate analog NIR dye OTL38 preoperatively. NIR fluorescence signal-to-background ratio (SBR) was recorded for each tumor during resection of the adenomas. Extent of surgery was not modified based on the presence or absence of fluorescence. Immunohistochemistry was performed to assess FRα expression in all specimens. Magnetic resonance imaging (MRI) was performed postoperatively to assess residual neoplasm. RESULTS: Nine adenomas overexpressed FRα and fluoresced with a NIR SBR of 3.2 ± 0.52, whereas the 5 non-FRα-overexpressing adenomas fluoresced with an SBR of 1.5 ± 0.21. Linear regression demonstrated a significant correlation between intraoperative SBR and the FRα expression (P-value |
| تدمد: | 2332-4260 2332-4252 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dc15fc3adf345c1f5707900f0ad2a3Test https://doi.org/10.1093/ons/opy034Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b5dc15fc3adf345c1f5707900f0ad2a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23324260 23324252 |
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