Efficacy of Isotonic Seawater Solution on Inflammation of the Ocular Surface in Matrix Metalloproteinase MMP-9-Positive Dry Eye Disease Patients
| العنوان: | Efficacy of Isotonic Seawater Solution on Inflammation of the Ocular Surface in Matrix Metalloproteinase MMP-9-Positive Dry Eye Disease Patients |
|---|---|
| المؤلفون: | Romero Francisco Javier, Diaz-Guiñon Teresa, Diaz Maria, Pinazo-Duran Maria Dolores, Rahhal-Ortuño Miriam, Diaz-Llopis Manuel, Dolz-Marco Rosa, Diaz-Guiñon Loreto, Gallego-Pinazo Roberto |
| المصدر: | Open Journal of Ophthalmology. 10:211-219 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Metalloproteinase, medicine.medical_specialty, genetic structures, business.industry, Inflammation, Disease, Matrix metalloproteinase, eye diseases, Ophthalmology, medicine, Tears, Ocular Surface Disease Index, Seawater, sense organs, medicine.symptom, business, Prospective cohort study |
| الوصف: | Purpose: Prospective study to evaluate the anti-inflammatory efficacy of isotonic seawater solution on metalloproteinase 9 (MMP-9) levels in the tears of patients with dry eye disease (DED). Methods: A total of 50 patients were included, with the following dry eye criteria in both eyes: InflammaDry? test initially positive, ocular surface disease index (OSDI) score ≥ 12 and Results: The InflammaDry test was positive in 100% of the patients (n = 50) and in 100% (n = 100) of the eyes before treatment. In 14 (28%) patients the test became negative in both eyes, and in 15 (30%) it was negative in one of the eyes. In 43% (n = 43) of the positive eyes, MMP-9 became undetectable in the tear fluid following treatment with isotonic seawater. This change was statistically significant (p Conclusions: The washes with ophthalmic isotonic seawater solution have a significant impact on inflammation of the ocular surface in dry eye disease, with an ability to make MMP-9 levels negative in 43% of cases. |
| تدمد: | 2165-7416 2165-7408 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::a0762e0a832f70118a56a3254a155de9Test https://doi.org/10.4236/ojoph.2020.103023Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........a0762e0a832f70118a56a3254a155de9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21657416 21657408 |
|---|