A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension
| العنوان: | A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension |
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| المؤلفون: | Catherine Cluver, Fiona C Brownfoot, Manarangi De Silva, Natalie J. Hannan, Stephen Tong, Susan P. Walker, Roxanne Hastie, Anthea Lindquist |
| المصدر: | Open Journal of Obstetrics and Gynecology. :21-28 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Gestational hypertension, Pregnancy, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, business.industry, Lansoprazole, medicine.disease, Placebo, law.invention, Preeclampsia, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Medicine, 030212 general & internal medicine, business, Cohort study, medicine.drug |
| الوصف: | Background: Preeclampsia is a hypertensive disorder of pregnancy with a high rate of neonatal and maternal morbidity and mortality. The only definitive treatment is delivery. Through pre-clinical studies, proton pump inhibitors (PPIs), which are commonly and safely used in pregnancy, have been identified as potential therapeutic agents. Objective: To undertake a systematic review evaluating PPIs in the prevention and/or treatment of preeclampsia and gestational hypertension. Search strategy: Electronic databases were searched from inception to 2018. Search terms included preeclampsia, proton-pump inhibitors, pregnancy-induced hypertension, lansoprazole, rabeprazole, esomeprazole and omeprazole. Selection criteria: Studies were included if they were randomized control trials, case-control or cohort studies on human subjects. Case reports, review articles, opinion pieces and conference abstracts were excluded as well as studies with no or inappropriate control arms. Data collection and analysis: Only one eligible study was identified, so no analyses were able to be performed. Main results: There was only one clinical trial eligible for inclusion. This was a randomized clinical trial investigating the role of PPIs in the treatment of preterm preeclampsia in a high-risk, inpatient setting. This was a negative finding, with no change in the primary outcome of prolongation of gestation between the PPI group and placebo control. Conclusion: There is a scarcity of clinical trials published investigating the therapeutic potential of PPIs for preeclampsia and gestational hypertension. Of the one available study, PPIs were not found to prolong gestation among preterm preeclamptic patients compared to placebo control. In order to further elucidate the clinical potential of PPIs to prevent or treat preeclampsia, further trials are required. |
| تدمد: | 2160-8806 2160-8792 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::86bf4c306729a24a602585af6a1a87b1Test https://doi.org/10.4236/ojog.2019.91003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........86bf4c306729a24a602585af6a1a87b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21608806 21608792 |
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