Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase
| العنوان: | Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase |
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| المؤلفون: | Annalisa Camporeale, Roberto Taramelli, Paolo Ghia, Laura Monti, Katia Rea, Francesco Acquati, Elena Monti, Marta Lualdi, Debora Scaldaferri, Antonella Tomassetti, Edoardo Pedrini, Marzia B. Gariboldi |
| المساهمون: | Lualdi, M, Pedrini, E, Rea, K, Monti, L, Scaldaferri, D, Gariboldi, M, Camporeale, A, Ghia, PAOLO PROSPERO, Monti, E, Tomassetti, A, Acquati, F, Taramelli, R. |
| المصدر: | Scopus-Elsevier Oncotarget Europe PubMed Central |
| بيانات النشر: | Impact Journals, LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Microenvironment, Ovarian cancer, RNase, Stress response, RNase P, Mice, Nude, Cell Growth Processes, Biology, Molecular oncology, Actin cytoskeleton organization, Mice, Ribonucleases, Cell Movement, Cell Line, Tumor, Tumor Microenvironment, medicine, Animals, Humans, Ovarian Neoplasms, Genetics, Tumor microenvironment, Tumor Suppressor Proteins, Cancer, medicine.disease, Molecular medicine, Cell Hypoxia, Oncology, Cancer cell, Heterografts, Female, Signal transduction, Research Paper, HeLa Cells, Signal Transduction |
| الوصف: | // Marta Lualdi 1 , Edoardo Pedrini 1 , Katia Rea 2 , Laura Monti 1 , Debora Scaldaferri 1 , Marzia Gariboldi 3 , Annalisa Camporeale 4,6 , Paolo Ghia 4,5 , Elena Monti 3 , Antonella Tomassetti 2 , Francesco Acquati 1 and Roberto Taramelli 1 1 Department of Theoretical and Applied Sciences, Universita degli Studi dell’Insubria, Varese, Italy 2 Unit of Molecular Therapies, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 3 Department of Theoretical and Applied Sciences, Universita degli Studi dell’Insubria, Busto Arsizio, Italy 4 Division of Molecular Oncology and Department of Onco-Hematology, IRCCS Ospedale San Raffaele, Milan, Italy 5 Universita Vita-Salute San Raffaele, Milan, Italy 6 Present address: Molecular Biotechnology Center and Department of Molecular Biotechnology and Life Sciences, University of Turin, Turin, Italy Correspondence to: Francesco Acquati, email: // Keywords : RNase, Ovarian cancer, Microenvironment, Stress response Received : December 01, 2014 Accepted : February 02, 2015 Published : March 08, 2015 Abstract As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this gene is an extracellular RNase which is able to control cancer growth in a non-cell autonomous mode by inducing a sustained recruitment of immune-competent cells belonging to the monocyte/macrophage lineage within a growing tumor mass. Here, we asked whether this oncosuppressor gene is sensitive to stress challenges and whether it can trigger cell-intrinsic processes as well. Indeed, RNASET2 expression levels were consistently found to increase following stress induction. Moreover, changes in RNASET2 expression levels turned out to affect several cancer-related parameters in vitro in an ovarian cancer cell line model. Of note, a remarkable rearrangement of the actin cytoskeleton organization, together with changes in cell adhesion and motility, emerged as putative mechanisms by which such cell-autonomous role could occur. Altogether, these biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation. |
| تدمد: | 1949-2553 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5512cf4052aa028b74ea1f652ca489bTest https://doi.org/10.18632/oncotarget.3490Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e5512cf4052aa028b74ea1f652ca489b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19492553 |
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