Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas
| العنوان: | Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas |
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| المؤلفون: | Hai-Yan Xie, Li-Ke Yu, Zhang Yu, Ping Zhan, Ning Xia, Ke-Ke Hao, Xiao-Kun Shen, Chuen-Hua Xu, Wei Hu, Ji-ping Zhu, Qin Wang, Qian Qian, Guo-Jun Lu |
| المصدر: | Oncology Reports |
| بيانات النشر: | Spandidos Publications, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Cancer Research, Pathology, Lung Neoplasms, Time Factors, Caveolin 1, Kaplan-Meier Estimate, Risk Factors, Carcinoma, Non-Small-Cell Lung, Aged, 80 and over, Articles, General Medicine, Middle Aged, Cell cycle, Immunohistochemistry, Tumor Burden, Up-Regulation, Treatment Outcome, medicine.anatomical_structure, Real-time polymerase chain reaction, Oncology, Lymphatic Metastasis, Carcinoma, Squamous Cell, cardiovascular system, Adenocarcinoma, Female, Adult, caveolin-1, China, medicine.medical_specialty, Adolescent, Blotting, Western, Adenocarcinoma of Lung, Biology, Real-Time Polymerase Chain Reaction, Risk Assessment, Young Adult, Biomarkers, Tumor, medicine, Humans, Neoplasm Invasiveness, RNA, Messenger, non-small cell lung cancer, Aged, Neoplasm Staging, Lung, Oncogene, Cancer, medicine.disease, Molecular medicine, respiratory tract diseases, immunohistochemical staining, Case-Control Studies, prognosis, real-time PCR |
| الوصف: | Caveolin-1 (cav-1) has been implicated in the development of human cancers. However, the distribution of cav-1 in non-small cell lung cancer (NSCLC) and its significance require further study. Real-time PCR and Western blot assays were performed to detect cav-1 mRNA and protein levels in tumor tissues (TT) and matched tumor-free tissues (TF). The protein expression in 115 paraffin-embedded blocks was examined by immunohistochemical staining (IHC). Correlations between cav-1 mRNA and protein expression by IHC and clinicopathological features were statistically evaluated. For the 136 patients examined, the levels of cav-1 mRNA and protein expression were significantly lower in lung TT compared to matched TF (P |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77d43e55c8b21dfb8edb2cb967289feTest https://doi.org/10.3892/or.2011.1605Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a77d43e55c8b21dfb8edb2cb967289fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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