New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma
| العنوان: | New insights and future perspectives in the therapeutic strategy of adrenocortical carcinoma |
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| المؤلفون: | Pina Lardo, Antonio Stigliano, Lidia Cerquetti, Elisa Petrangeli, Vincenzo Toscano |
| المصدر: | Oncology Reports. 37:1301-1311 |
| بيانات النشر: | Spandidos Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Cortisol secretion, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Antineoplastic Agents, 030209 endocrinology & metabolism, Malignancy, Adjuvant therapy, Adrenocortical carcinoma, Chemotherapy, Mitotane, Targeted therapy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Adrenocortical Carcinoma, medicine, Animals, Humans, Radical surgery, business.industry, Cancer, General Medicine, medicine.disease, Adrenal Cortex Neoplasms, Radiation therapy, Vascular endothelial growth factor, chemistry, 030220 oncology & carcinogenesis, Immunology, business, medicine.drug |
| الوصف: | Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an incidence ranging from 0.7 to 2.0 cases/million people per year. Hypercortisolism represents the most common clinical presentation in many patients although, less frequently, some ACC secreting androgens and estrogens are even more pathognomonic compared to cortisol secretion. Currently, radical surgery, when feasible, is still the only curative therapy. Mitotane, an adrenolytic drug, is used in the adjuvant setting and in combination with chemotherapy drugs in metastatic disease. The use of radiotherapy remains controversial, being indicated only in selected cases. New targeted therapies, such as insulin growth factor-1 (IGF-1), mammalian-target of rapamycin (m-TOR), vascular endothelial growth factor (VEGF) inhibitors and others, have recently been investigated with disappointing clinical results. The partial effectiveness of current treatments mandates the need for new therapeutic strategies against this tumor. |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b56cb4800de06caba3ff5f60d487158Test https://doi.org/10.3892/or.2017.5427Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b56cb4800de06caba3ff5f60d487158 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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