التفاصيل البيبلوغرافية
| العنوان: |
Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma. |
| المؤلفون: |
JACOBY, ELAD, YALON, MICHAL, LEITNER, MOSHE, COHEN, ZVI R., COHEN, YEHUDIT, FISHER, TAMAR, EDER, SARIT, AMARIGLIO, NINETTE, RECHAVI, GIDEON, CAZACU, SIMONA, XIANG, CUNLI, MIKKELSEN, TOM, BRODIE, CHAYA, TOREN, AMOS |
| المصدر: |
Oncology Letters; 2014, Vol. 7 Issue 4, p1209-1212, 4p |
| مصطلحات موضوعية: |
TESTICULAR proteins, GLIOBLASTOMA multiforme, METHYLATION, PROMOTERS (Genetics), PROSTATE cancer & genetics, NEPHROBLASTOMA, GENETICS |
| مستخلص: |
Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization classIV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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