Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells
| العنوان: | Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells |
|---|---|
| المؤلفون: | Sai‑Jun Fan, Fu‑Zheng Zhang, Chao‑Qian Zhao, Xu‑Dong Hu, Jun Che |
| المصدر: | Oncology Letters |
| بيانات النشر: | D.A. Spandidos, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Cyclopamine, proliferation, Estrogen receptor, Biology, medicine.disease_cause, chemistry.chemical_compound, Cyclin D1, breast cancer, estrogen receptor-α, Internal medicine, medicine, cyclopamine, MAPK/ERK, Hedgehog, Cancer, Articles, medicine.disease, invasion, Hedgehog signaling pathway, Endocrinology, Oncology, chemistry, Cancer cell, Cancer research, Carcinogenesis |
| الوصف: | Stimulation of Hedgehog (Hh) signaling induces carcinogenesis or promotes cell survival in cancers of multiple organs. In epithelial cancer with aberrant Hedgehog activation, abrogation of Hedgehog signaling by cyclopamine, a naturally occurring Hedgehog-specific small-molecule inhibitor, causes profound inhibition of tumor growth. In the present study, cyclopamine displayed a significant potency in suppressing the proliferation of both estrogen-responsive (MCF-7) and estrogen-independent (MDA-MB-231) human breast cancer cells. Cyclopamine induced a robust G1 cell cycle arrest and elicited notable effects on the expression of cyclin D1 through modulation of the MAPK/ERK signaling pathway. Cyclopamine also inhibited the invasive ability of both breast cancer cell lines by suppressing the expression levels of NF-κB, MMP2 and MMP9 protein. Furthermore, in estrogen-responsive MCF-7 cells, cyclopamine significantly downregulated the production of estrogen receptor-α protein. Our results implicate cyclopamine as a novel, potent inhibitor of human breast cancer proliferation and estrogen responsiveness that could potentially be developed into a promising therapeutic agent for the treatment of breast cancer. |
| اللغة: | English |
| تدمد: | 1792-1082 1792-1074 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b2588daf7aaa8227ba27139296b6f2Test http://europepmc.org/articles/PMC3629107Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26b2588daf7aaa8227ba27139296b6f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
|---|