Clinical significance and effect of Sam68 expression in gastric cancer
| العنوان: | Clinical significance and effect of Sam68 expression in gastric cancer |
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| المؤلفون: | Fulin Qiang, Qichang Yang, Song He, Qiuhong Wang, Hua Wang, Lei Yang, Jin Cai, Yingying Wang, Jinzhang Xiao |
| المصدر: | Oncology Letters |
| بيانات النشر: | D.A. Spandidos, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Oncogene, business.industry, gastric cancer, proliferation, Cancer, Articles, Cell cycle, Src-associated in mitosis of 68 kDa, medicine.disease, Malignancy, medicine.disease_cause, migration, Molecular medicine, Metastasis, 03 medical and health sciences, 030104 developmental biology, Oncology, Cancer cell, medicine, Cancer research, metastasis, business, Carcinogenesis |
| الوصف: | Gastric cancer is one of the most common types of malignancy worldwide. However, the molecular mechanisms of cancer development remain unclear. Src-associated in mitosis of 68 kDa (Sam68) is involved in cell proliferation, transformation, tumorigenesis and metastasis in several types of cancer. The present study aimed to assess the expression and function of Sam68 in human gastric cancer. Western blot analysis and immunohistochemistry indicated that Sam68 expression was increased in tumor samples and the levels were associated with the grade of malignancy. High Sam68 expression was associated with the poor prognosis of patients with gastric cancer. In vitro, following knockdown of Sam68 by transfection of gastric cancer cells with small interfering RNA, the cell viability, cell cycle progress, migration and invasion were decreased. The results of the present study revealed that Sam68 may be a novel prognostic factor for, and is associated with cell growth, migration and invasion in, gastric cancer. |
| اللغة: | English |
| تدمد: | 1792-1082 1792-1074 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8335247b4231a4b806c18902f6a2853aTest http://europepmc.org/articles/PMC5840748Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8335247b4231a4b806c18902f6a2853a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921082 17921074 |
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