Fibroblast growth factor signaling in mammalian tooth development
| العنوان: | Fibroblast growth factor signaling in mammalian tooth development |
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| المؤلفون: | Jan Prochazka, Alice F. Goodwin, Chun-Ying Li, Ophir D. Klein |
| المصدر: | Odontology |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, Fibroblast growth factor, Article, Receptor tyrosine kinase, FGF and mesoderm formation, Cell biology, Fibroblast Growth Factors, Mice, stomatognathic diseases, Odontoblast, Endocrinology, stomatognathic system, Human tooth development, Internal medicine, biology.protein, medicine, Animals, Humans, Signal transduction, Cell adhesion, Ameloblast, Tooth, General Dentistry, Signal Transduction |
| الوصف: | In this review, we discuss the central role of fibroblast growth factor (FGF) signalling in mammalian tooth development. The FGF family consists of 22 members, most of which bind to four different receptor tyrosine kinases, which in turn signal through a cascade of intracellular proteins. This signaling regulates a number of cellular processes, including proliferation, differentiation, cell adhesion and cell mobility. FGF signaling first becomes important in the presumptive dental epithelium at the initiation stage of tooth development, and subsequently, it controls the invagination of the dental epithelium into the underlying mesenchyme. Later, FGFs are critical in tooth shape formation and differentiation of ameloblasts and odontoblasts, as well as in the development and homeostasis of the stem cell niche that fuels the continuously growing mouse incisor. In addition, FGF signaling is critical in human teeth, as mutations in genes encoding FGF ligands or receptors result in several congenital syndromes characterized by alterations in tooth number, morphology or enamel structure. The parallel roles of FGF signaling in mouse and human tooth development demonstrate the conserved importance of FGF signaling in mammalian odontogenesis. |
| تدمد: | 1618-1255 1618-1247 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3abe059631666f2ac75aa3bbb066cd9Test https://doi.org/10.1007/s10266-013-0142-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f3abe059631666f2ac75aa3bbb066cd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16181255 16181247 |
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