التفاصيل البيبلوغرافية
| العنوان: |
Mesalazine Suppresses Proinflammatory Cytokines in Patients with Acute Anterior Uveitis Independently of HLA-B27. |
| المؤلفون: |
Smatlik, Nikola, Mortada, Nourhan, Röcken, Martin, Yazdi, Amir S., Zierhut, Manfred |
| المصدر: |
Ocular Immunology & Inflammation; Aug2022, Vol. 30 Issue 6, p1369-1377, 9p |
| مصطلحات موضوعية: |
HLA-B27 antigen, IRIDOCYCLITIS, MESALAMINE, CYTOKINES |
| الشركة/الكيان: |
AMATEUR Athletic Union of the United States |
| مستخلص: |
The aim is to unravel the mechanism of mesalazine (5-ASA) on proinflammatory cytokines in PBMCs of patients with HLA-B27 +and HLA-B27 -acute anterior uveitis (AAU), and whether this may explain the different effects of 5-ASA in both disoders. PBMCs from 12 HLA-B27+ and 4 HLA-B27- AAU patients were preincubated with 5-ASA and stimulated with LPS. As mesalazine (5-ASA) could be involved in ER stress, proinflammatory and ER stress-associated cytokines and markers were measured. Mesalazine (5-ASA) suppressed IL-6 mRNA in healthy donors and in HLA-B27+ and HLA-B27- patients but did not lead to induction and secretion of IL-1β. In HLA-B27 + or – patients the ER stress-associated markers CHOP (DDIT3) and ATF6 were suppressed. Here we show that mesalazine (5-ASA) inhibits the transcription of proinflammatory and (ER) stress associated cytokines and markers, independently of the HLA-B27 status. Results show the similarities of both AAU types but do not decipher the mechanism why the HLA-B27 status determines the therapeutic response to mesalazine in AAU. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
