Changes in vitamin D and matrix metalloproteinase-9 in submariners during a submerged patrol
| العنوان: | Changes in vitamin D and matrix metalloproteinase-9 in submariners during a submerged patrol |
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| المؤلفون: | A M Wood, A Baker, Claire L Wood, A J Allsopp, P Timms |
| المصدر: | Occupational and Environmental Medicine. 71:104-108 |
| بيانات النشر: | BMJ, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Analysis of Variance, Time Factors, Submarine Medicine, Submarine medicine, business.industry, Public Health, Environmental and Occupational Health, Matrix metalloproteinase 9, On board, Military Personnel, Animal science, Matrix Metalloproteinase 9, Adverse health effect, Vitamin D and neurology, Humans, Medicine, Female, Prospective Studies, Vitamin D, Inverse correlation, Prospective cohort study, business, Biomarkers |
| الوصف: | Objectives To quantify changes in vitamin D and matrix metalloproteinase-9 (MMP9) in submariners over a single long patrol and compare the data to a group of non-deploying servicemen from their base port. Methods A prospective time-series analysis was performed. Blood samples were taken from 49 submariners deploying on patrol and 43 shore-side controls from the base port (naval officers from base or non-deploying submariners), following a winter ashore at latitude 56° north. Samples were drawn immediately before the submarine sailed, in January, and again in the final week of patrol 85 days later. Paired pre-patrol and late samples from each individual were assayed together and changes in vitamin D and MMP9 were assessed. Results Mean pre-patrol vitamin D concentrations were 58 and 49 nmol/L for the controls and submariners, respectively. Mean vitamin D concentrations increased in controls as expected (mean increase 12.6 nmol/L), but not in the submariners (mean decrease 1.6 nmol/L). MMP9 levels were significantly higher in submariners pre-patrol, and increased significantly during the patrol. There was a significant inverse correlation between MMP9 and vitamin D levels (r=−0.41, p=0.01). Conclusions This is the first study to quantify vitamin D and MMP levels in submariners. Circulating vitamin D concentrations on board were insufficient to prevent a rise in MMP. This has potential for adverse health effects and requires further study. |
| تدمد: | 1470-7926 1351-0711 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dfe3c84c544e049832b81e91729c8eTest https://doi.org/10.1136/oemed-2013-101793Test |
| رقم الانضمام: | edsair.doi.dedup.....88dfe3c84c544e049832b81e91729c8e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14707926 13510711 |
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