التفاصيل البيبلوغرافية
| العنوان: |
Differential Impact of Weight Loss and Glycemic Control on Inflammasome Signaling. |
| المؤلفون: |
Antonioli, Luca, Moriconi, Diego, Masi, Stefano, Bottazzo, Dario, Pellegrini, Carolina, Fornai, Matteo, Anselmino, Marco, Ferrannini, Ele, Blandizzi, Corrado, Taddei, Stefano, Nannipieri, Monica |
| المصدر: |
Obesity (19307381); Mar2020, Vol. 28 Issue 3, p609-615, 7p |
| مصطلحات موضوعية: |
GASTRIC bypass, WEIGHT loss, GLYCEMIC control, MORBID obesity, TYPE 2 diabetes, PATHOLOGY, INFLAMMASOMES, PROTEINS, CELL differentiation, RESEARCH, HUMAN research subjects, RESEARCH methodology, INTERLEUKIN-1, BLOOD sugar, EVALUATION research, MEDICAL cooperation, CELLULAR signal transduction, COMPARATIVE studies, RESEARCH funding |
| مستخلص: |
Objective: Interleukin (IL)-1β is involved in obesity-associated inflammation and in the pathogenesis of type 2 diabetes (T2D) mellitus. Our aim was to correlate serum IL-1β and caspase-1 levels with weight loss, glucose metabolism, and insulin resistance (IR) after bariatric surgery.Methods: A total of 32 patients with morbid obesity and T2D (Ob-T2D) and 29 patients with morbid obesity and normal glucose tolerance (Ob-NGT), treated by Roux-en-Y gastric bypass, were studied before and 1 year after surgery. Sixteen healthy individuals served as a control (HC) group. IR was assessed by the oral glucose insulin sensitivity method. Plasma IL-1β levels and caspase-1 were measured.Results: Presurgery BMI was similar in Ob-NGT and Ob-T2D. IR was progressively impaired in Ob-NGT and Ob-T2D (P < 0.0001). Fasting plasma IL-1β and caspase-1 levels were lower in HCs than in patients with Ob-NGT or Ob-T2D (P < 0.02; P = 0.05), and both were inversely correlated with IR (P = 0.01; P = 0.02). After surgery, BMI decreased and IR improved to a similar extent in Ob-NGT and Ob-T2D (P < 0.0001). Plasma caspase-1 concentrations normalized in both groups (P < 0.0001), whereas plasma IL-1β levels normalized only in Ob-NGT.Conclusions: Plasma IL-1β and caspase-1 levels were inversely correlated with IR. Caspase-1 levels normalized after weight loss, whereas IL-1β normalized only in people without T2D, suggesting the persistence of a systemic inflammatory condition in people with T2D. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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