التفاصيل البيبلوغرافية
| العنوان: |
The Macrophage-Specific Serum Marker, Soluble CD163, Is Increased in Obesity and Reduced After Dietary-Induced Weight Loss. |
| المؤلفون: |
Fjeldborg, Karen, Christiansen, Tore, Bennetzen, Marianne, J. Møller, Holger, Pedersen, Steen B., Richelsen, Bjørn |
| المصدر: |
Obesity (19307381); Dec2013, Vol. 21 Issue 12, p2437-2443, 7p |
| مصطلحات موضوعية: |
MACROPHAGES, OBESITY, TYPE 2 diabetes risk factors, WEIGHT loss, INSULIN resistance, REDUCING diets |
| مستخلص: |
Objective: Soluble CD163 (sCD163) is a new macrophage-specific serum marker elevated in inflammatory conditions. sCD163 is elevated in obesity and found to be a strong predictor of the development of type 2 diabetes. We investigated whether dietary intervention and moderate exercise was related to changes in sCD163 and how sCD163 is associated to insulin resistance in obesity. Design and Methods: Ninety-six obese subjects were enrolled: 62 followed a very low energy diet (VLED) program for 8 weeks followed by 3-4 weeks of weight stabilization, 20 followed a moderate exercise program for 12 weeks, and 14 were included without any intervention. Fasting blood samples and anthropometric measures were taken at baseline and after intervention. Thirty-six lean subjects were included in a control group. Results: sCD163 was significantly higher in obese subjects (2.3 ± 1.0 mg/l) compared with lean (1.6 ± 0.4 mg/l, P < 0.001). Weight loss (11%) induced by VLED resulted in a reduction and partial normalization of sCD163 to 2.0 ± 0.9 mg/l ( P < 0.001). Exercise for 12 weeks had no effect on sCD163. At baseline, sCD163 was significantly correlated with BMI ( r = 0.46), waist circumference ( r = 0.40), insulin resistance measured by the homeostasis model assessment (HOMA-IR; r = 0.41; all P < 0.001), and the leptin-to-adiponectin ratio ( r = 0.28, P < 0.05). In a multivariate linear regression analysis with various inflammatory markers, sCD163 ( β = 0.25), adiponectin ( β = −0.24), and high sensitivity C-reactive protein (hs-CRP; β = 0.20) remained independently and significantly associated to HOMA-IR (all P < 0.05). After further adjustment for waist circumference, only sCD163 was associated with HOMA-IR ( P < 0.05). Conclusion: The macrophage-specific serum marker sCD163 is increased in obesity and partially normalized by dietary-induced weight loss but not by moderate exercise. Furthermore, we confirm that sCD163 is a good marker for obesity-related insulin resistance. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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