التفاصيل البيبلوغرافية
| العنوان: |
Vitamin C Supplementation Decreases Oxidative Stress Biomarker F2-Isoprostanes in Plasma of Nonsmokers Exposed to Environmental Tobacco Smoke. |
| المؤلفون: |
Dietrich, Marion, Block, Gladys, Benowitz, Neal L., Morrow, Jason D, Hudes, Mark, Jacob, Peyton, Norkus, Edward P., Packer, Lester |
| المصدر: |
Nutrition & Cancer; 2003, Vol. 45 Issue 2, p176-184, 9p |
| مصطلحات موضوعية: |
VITAMIN C, LUNG cancer, CARDIOVASCULAR diseases, ANTIOXIDANTS, PEROXIDATION |
| مستخلص: |
Exposure to environmental tobacco smoke (ETS) has been linked to increased risk of lung cancer and cardiovascular diseases in nonsmokers. Current research suggests that some of these diseases are associated with elevated oxidative stress. We investigated the effect of antioxidant (AO) intervention on the lipid peroxidation biomarker F[SUB2]-isoprostanes (F[SUB2]-IsoPs), an index of oxidative stress, in plasma of nonsmokers exposed to ETS (passive smokers). We measured free F[SUB2]-IsoP concentrations in plasma of 67 passive smokers at baseline and after 2 mo of daily intervention with AOs or placebo. The study subjects (47 females, 20 males; mean age 46 ± 15) were randomized into one of three treatment groups: vitamin C, "mixture" (vitamin C, vitamin E, and α-lipoic-acid), and placebo. Investigated confounders included plasma baseline AO levels, lipid and total cholesterol profiles, transferrin saturation, and C-reactive protein. Plasma F[SUB2] IsoP concentrations of subjects in the vitamin C and mixture groups decreased significantly by 17.2 pmol/l (P = 0.0105) and 19.2 pmol/l (P = 0.0083) when compared with the placebo group (11.4% and 12.7%, respectively). Daily AO supplementation (especially with vitamin C) decreases this oxidative stress biomarker in passive smokers. This finding might be of importance for the prevention of ETS-associated adverse health effects in nonsmokers. [ABSTRACT FROM AUTHOR] |
|
Copyright of Nutrition & Cancer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
