التفاصيل البيبلوغرافية
| العنوان: |
Food Sources of Fat and Sex Hormone Receptor Status of Invasive Breast Tumors in Women of the Malmo Diet and Cancer Cohort. |
| المؤلفون: |
Wirfält, Elisabet, Li, Cairu, Manjer, Jonas, Ericson, Ulrika, Sonestedt, Emily, Borgquist, Signe, Landberg, Göran, Olsson, Håkan, Gullberg, Bo |
| المصدر: |
Nutrition & Cancer; 2011, Vol. 63 Issue 5, p722-733, 12p |
| مصطلحات موضوعية: |
CELL receptors, ANALYSIS of variance, BODY weight, BREAST tumors, CONFIDENCE intervals, DIET, FAT, INGESTION, LONGITUDINAL method, NUTRITION, STATURE, TUMORS, DATA analysis, BODY mass index, PROPORTIONAL hazards models, WAIST-hip ratio, SEDENTARY lifestyles, DATA analysis software, CELL physiology |
| مستخلص: |
We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmo Diet and Cancer cohort (∼17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59) and dried soups/sauces (HR = 1.31 95% CI = 1.05-1.64) showed increased risks. Heterogeneity was observed between ER+PR+ and ER-PR- tumors for vegetable-oil-based margarine (P < 0.01). Regular milk showed decreased, and dried soups/sauces increased, risk with all breast cancer. The study suggests that fat-containing food may contribute both to hormonal and nonhormonal mechanisms in breast tumor development and supports observations of positive associations between characteristics of Westernized diets and postmenopausal breast cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
