Prognostic Effect of a Novel Simply Calculated Nutritional Index in Acute Decompensated Heart Failure
| العنوان: | Prognostic Effect of a Novel Simply Calculated Nutritional Index in Acute Decompensated Heart Failure |
|---|---|
| المؤلفون: | Hiroki Matsumoto, Takatoshi Kasai, Yuya Matsue, Ryo Naito, Shinichiro Doi, Jun Shitara, Megumi Shimizu, Atsutoshi Takagi, Hiroyuki Daida, Hiroshi Iwata, Shoichiro Yatsu, Akihiro Sato, Takao Kato, Azusa Murata, Masaru Hiki, Sayaki Ishiwata, Shoko Suda |
| المصدر: | Nutrients Nutrients, Vol 12, Iss 3311, p 3311 (2020) Volume 12 Issue 11 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, acute decompensated heart failure, Acute decompensated heart failure, Serum sodium level, lcsh:TX341-641, 030204 cardiovascular system & hematology, Risk Assessment, Gastroenterology, Article, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, nutritional index, Internal medicine, medicine, Humans, 030212 general & internal medicine, Geriatric Assessment, Triglycerides, Aged, Proportional Hazards Models, Retrospective Studies, Aged, 80 and over, Heart Failure, Nutrition and Dietetics, business.industry, Body Weight, Hazard ratio, Middle Aged, Prognosis, medicine.disease, Confidence interval, Net reclassification improvement, Survival Rate, Cholesterol, Nutrition Assessment, Heart Disease Risk Factors, Acute Disease, Coronary care unit, Female, Hemoglobin, Diet, Healthy, business, lcsh:Nutrition. Foods and food supply, Food Science |
| الوصف: | The TCB index (triglycerides × total cholesterol × body weight), a novel simply calculated nutritional index based on serum triglycerides (TGs), serum total cholesterol (TC), and body weight (BW), was recently reported to be a useful prognostic indicator in patients with coronary artery disease. Thus, this study aimed to investigate the relationship between TCBI and long-term mortality in acute decompensated heart failure (ADHF) patients. Patients with a diagnosis of ADHF who were consecutively admitted to the cardiac intensive care unit in our institution from 2007 to 2011 were targeted. TCBI was calculated using the formula TG (mg/dL) × TC (mg/dL) × BW (kg)/1000. Patients were divided into two groups according to the median TCBI value. An association between admission TCBI and mortality was assessed using univariable and multivariable Cox proportional hazard analyses. Overall, 417 eligible patients were enrolled, and 94 (22.5%) patients died during a median follow-up period of 2.2 years. The cumulative survival rate with respect to all-cause, cardiovascular, and cancer-related mortalities was worse in patients with low TCBI than in those with high TCBI. In the multivariable analysis, although TCBI was not associated with cardiovascular and cancer mortalities, the association between TCBI and reduced all-cause mortality (hazard ratio: 0.64, 95% confidence interval: 0.44&ndash 0.94, p = 0.024) was observed. We computed net reclassification improvement (NRI) when TCBI or Geriatric Nutritional Risk Index (GNRI) was added on established predictors such as hemoglobin, serum sodium level, and both. TCBI improved discrimination for all-cause mortality (NRI: 0.42, p < 0.001 when added on hemoglobin and serum sodium level). GNRI can improve discrimination for cancer mortality (NRI: 0.96, p = 0.002 when added on hemoglobin and serum sodium level). TCBI, a novel and simply calculated nutritional index, can be useful to stratify patients with ADHF who were at risk for worse long-term overall mortality. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3630dc64e276a94e7be0f5783a80634Test https://doi.org/10.3390/nu12113311Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e3630dc64e276a94e7be0f5783a80634 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
|---|