High Plasma Docosahexaenoic Acid Associated to Better Prognoses of Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction
| العنوان: | High Plasma Docosahexaenoic Acid Associated to Better Prognoses of Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction |
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| المؤلفون: | Masafumi Tanimoto, Naoaki Matsuo, Hiroshi Ito, Nobuhiko Onishi, Takao Kishinoue, Masayuki Ueeda, Yukari Nakano, Toru Miyoshi, Kentaro Yasuhara, Atsushi Takaishi |
| المصدر: | Nutrients Nutrients, Vol 13, Iss 371, p 371 (2021) Volume 13 Issue 2 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Acute decompensated heart failure, 030204 cardiovascular system & hematology, Gastroenterology, chemistry.chemical_compound, Plasma, 0302 clinical medicine, 8,11,14-Eicosatrienoic Acid, Risk Factors, Cause of Death, 030212 general & internal medicine, chemistry.chemical_classification, Aged, 80 and over, Nutrition and Dietetics, Ejection fraction, Arachidonic Acid, food and beverages, geriatric nutritional risk index, docosahexaenoic acid, Prognosis, Eicosapentaenoic acid, Eicosapentaenoic Acid, Docosahexaenoic acid, Fatty Acids, Unsaturated, Arachidonic acid, lipids (amino acids, peptides, and proteins), Female, lcsh:Nutrition. Foods and food supply, Polyunsaturated fatty acid, heart failure with preserved ejection fraction, medicine.medical_specialty, Docosahexaenoic Acids, Nutritional Status, lcsh:TX341-641, Article, 03 medical and health sciences, Internal medicine, medicine, Humans, Aged, Retrospective Studies, Heart Failure, business.industry, Stroke Volume, medicine.disease, chemistry, Heart failure, Heart failure with preserved ejection fraction, business, Food Science |
| الوصف: | The clinical relevance of polyunsaturated fatty acids (PUFAs) in heart failure remains unclear. The aim of this study was to investigate the association between PUFA levels and the prognosis of patients with heart failure with preserved ejection fraction (HFpEF). This retrospective study included 140 hospitalized patients with acute decompensated HFpEF (median age 84.0 years, 42.9% men). The patients&rsquo nutritional status was assessed, using the geriatric nutritional risk index (GNRI), and their plasma levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-gamma-linolenic acid (DGLA) were measured before discharge. The primary outcome was all-cause mortality. During a median follow-up of 23.3 months, the primary outcome occurred in 37 patients (26.4%). A Kaplan&ndash Meier analysis showed that lower DHA and DGLA levels, but not EPA or AA levels, were significantly associated with an increase in all-cause death (log-rank p < 0.001 and p = 0.040, respectively). A multivariate Cox regression analysis also revealed that DHA levels were significantly associated with the incidence of all-cause death (HR: 0.16, 95% CI: 0.06&ndash 0.44, p = 0.001), independent of the GNRI. Our results suggest that low plasma DHA levels may be a useful predictor of all-cause mortality and potential therapeutic target in patients with acute decompensated HFpEF. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135978cd7f03614a81ff8ddd29933390Test https://pubmed.ncbi.nlm.nih.gov/33530352Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....135978cd7f03614a81ff8ddd29933390 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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