Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses
| العنوان: | Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses |
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| المؤلفون: | Hiroshi Iwata, Masaru Hiki, Takao Kato, Tetsuro Miyazaki, Tomoyuki Shiozawa, Megumi Shimizu, Katsumi Miyauchi, Yurina Sugita, Azusa Murata, Tatsuro Aikawa, Shoko Suda, Takatoshi Kasai, Kazunori Shimada, Shohei Ouchi, Shuhei Takahashi, Hiroyuki Daida |
| المصدر: | Nutrients, Vol 9, Iss 9, p 956 (2017) Nutrients; Volume 9; Issue 9; Pages: 956 Nutrients |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Acute decompensated heart failure, 030204 cardiovascular system & hematology, Gastroenterology, chemistry.chemical_compound, 8,11,14-Eicosatrienoic Acid, 0302 clinical medicine, Risk Factors, Prospective Studies, 030212 general & internal medicine, Aged, 80 and over, chemistry.chemical_classification, Arachidonic Acid, Nutrition and Dietetics, polyunsaturated fatty acids (PUFAs), Confounding, Middle Aged, Eicosapentaenoic acid, Docosahexaenoic acid, Female, Arachidonic acid, lipids (amino acids, peptides, and proteins), lcsh:Nutrition. Foods and food supply, Polyunsaturated fatty acid, medicine.medical_specialty, Docosahexaenoic Acids, lcsh:TX341-641, Article, 03 medical and health sciences, Internal medicine, acute decompensated heart failure (ADHF), medicine, Humans, Clinical significance, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), Aged, Heart Failure, business.industry, dihomo-gamma-linolenic acid (DGLA), arachidonic acid (AA), geriatric nutritional risk index (GNRI), nutritional status, medicine.disease, Endocrinology, chemistry, Coronary care unit, business, Biomarkers, Food Science |
| الوصف: | The clinical significance of polyunsaturated fatty acids (PUFAs) in acute decompensated heart failure (ADHF) in various nutritional statuses remains unclear. For this study, we enrolled 267 patients with ADHF admitted to the cardiac intensive care unit at Juntendo University hospital between April 2012 and March 2014. The association between long-term mortality, the geriatric nutritional risk index (GNRI), and levels of PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) was investigated. The median age was 73 (64–82) years, and mortality was 29% (62 patients). The event-free survival rates for all-cause death were higher in patients with high PUFA levels or GNRI than in those with low PUFA levels or GNRI (p < 0.05 for all). In particular, high DGLA in the low-GNRI group and high DHA or AA in the high-GNRI group were associated with high event-free survival (p < 0.05 for all). After accounting for confounding variables, DHA, DGLA, and AA, but not EPA, were associated with long-term mortality (p < 0.01 for all). This study concludes that in patients with ADHF, decreased levels of DHA, DGLA, and AA are independently associated with long-term mortality in the various nutritional statuses. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56b82986648c69b60faf7ff61f28d27Test https://www.mdpi.com/2072-6643/9/9/956Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b56b82986648c69b60faf7ff61f28d27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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