Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics
| العنوان: | Strong oral plaque microbiome signatures for dental implant diseases identified by strain-resolution metagenomics |
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| المؤلفون: | Federico Dell’Acqua, Paolo Manghi, Federica Armanini, Nicola Segata, Romina Waldner, Francesco Tessarolo, Cristiano Tomasi, Edoardo Pasolli, Moreno Zolfo, Ester Dellasega, Alberto Bertelle, Mattia Bolzan, Paolo Ghensi |
| المساهمون: | Ghensi, P., Manghi, P., Zolfo, M., Armanini, F., Pasolli, E., Bolzan, M., Bertelle, A., Dell'Acqua, F., Dellasega, E., Waldner, R., Tessarolo, F., Tomasi, C., Segata, N. |
| المصدر: | NPJ BIOFILMS AND MICROBIOMES NPJ Biofilms and Microbiomes npj Biofilms and Microbiomes, Vol 6, Iss 1, Pp 1-12 (2020) |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, DNA, Bacterial, Male, medicine.medical_treatment, Disease, Applied Microbiology and Biotechnology, Microbiology, lcsh:Microbial ecology, Article, Bacterial genetics, Machine Learning, 03 medical and health sciences, 0302 clinical medicine, Mucositis, medicine, Humans, Microbiome, Dental implant, Phylogeny, Aged, Plaque, Aged, 80 and over, Dental Implants, Stomatitis, biology, Bacteria, business.industry, Case-control study, High-Throughput Nucleotide Sequencing, 030206 dentistry, Sequence Analysis, DNA, Middle Aged, biology.organism_classification, medicine.disease, Peri-Implantitis, 3. Good health, 030104 developmental biology, Metagenomics, Case-Control Studies, Immunology, lcsh:QR100-130, Female, Fusobacterium nucleatum, business, Biotechnology |
| الوصف: | Dental implants are installed in an increasing number of patients. Mucositis and peri-implantitis are common microbial–biofilm-associated diseases affecting the tissues that surround the dental implant and are a major medical and socioeconomic burden. By metagenomic sequencing of the plaque microbiome in different peri-implant health and disease conditions (113 samples from 72 individuals), we found microbial signatures for peri-implantitis and mucositis and defined the peri-implantitis-related complex (PiRC) composed by the 7 most discriminative bacteria. The peri-implantitis microbiome is site specific as contralateral healthy sites resembled more the microbiome of healthy implants, while mucositis was specifically enriched for Fusobacterium nucleatum acting as a keystone colonizer. Microbiome-based machine learning showed high diagnostic and prognostic power for peri-implant diseases and strain-level profiling identified a previously uncharacterized subspecies of F. nucleatum to be particularly associated with disease. Altogether, we associated the plaque microbiome with peri-implant diseases and identified microbial signatures of disease severity. |
| اللغة: | English |
| تدمد: | 2055-5008 |
| DOI: | 10.1038/s41522-020-00155-7 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ecdde2a1adf8e1d921c6d4d0127365Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b1ecdde2a1adf8e1d921c6d4d0127365 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20555008 |
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| DOI: | 10.1038/s41522-020-00155-7 |