المؤلفون: Benboubker, Lofti, Dimopoulos, Meletios A.¹, Dispenzieri, Angela², Catalano, John³, Belch, Andrew R.⁴, Cavo, Michele⁵, Pinto, Antonello⁶, Weisel, Katja⁷, Ludwig, Heinz⁸, Bahlis, Nizar⁹, Banos, Anne¹⁰, Tiab, Mourad¹¹, Delforge, Michel¹², Cavenagh, Jamie¹³, Geraldes, Catarina¹⁴, Je-Jung Lee¹⁵, Chen, Christine¹⁶, Oriol, Albert¹⁷, de la Rubia, Javier¹⁸, Lugui Qiu¹⁹

المصدر: New England Journal of Medicine. 9/4/2014, Vol. 371 Issue 10, p906-917. 12p. 3 Charts, 1 Graph.

مصطلحات موضوعية: *DRUG efficacy, *MULTIPLE myeloma, *STEM cell transplantation research, *PROGRESSION-free survival, *DISEASE progression

مستخلص: The article presents a study that compared the efficacy and safety of lenalidomide-dexamethasone in patients with newly diagnosed multiple myeloma who were eligible for stem-cell transplantation. The study aimed to achieve progression-free survival with continuous lenalidomide-dexamethasone as compared with melphalan-prednisone-thalidomide, and reveals the median progression with continuous lenalidomide-dexamethasone.

المؤلفون: Mateos, María-Victoria¹, Hernández, Miguel-Teodoro², Giraldo, Pilar³, de la Rubia, Javier, de Arriba, Felipe⁴, López Corral, Lucía¹, Rosiñol, Laura⁵, Paiva, Bruno¹, Palomera, Luis⁶, Bargay, Joan⁷, Oriol, Albert⁸, Prosper, Felipe, López, Javier⁹, Olavarría, Eduardo¹⁰, Quintana, Nuria, García, José-Luis, Bladé, Joan⁵, Lahuerta, Juan-José¹¹, San Miguel, Jesús-F.¹ sanmiguel@usal.es

المصدر: New England Journal of Medicine. 8/1/2013, Vol. 369 Issue 5, p438-447. 10p. 1 Diagram, 3 Charts, 1 Graph.

مصطلحات موضوعية: *MULTIPLE myeloma treatment, *CANCER treatment, *DEXAMETHASONE, *DRUG efficacy, *THERAPEUTICS research

مستخلص: The article discusses the results of a phase 3, randomized trial that examined the efficacy of induction therapy with lenalidomide and dexamethasone, followed by maintenance therapy with lenalidomide, in patients with high-risk smoldering multiple myeloma. Findings showed the progression to active disease is delayed with early treatment for patients with high-risk smoldering myeloma. It also shows that early treatment increases overall survival.