التفاصيل البيبلوغرافية
| العنوان: |
Modulation of Blood Pressure by Central Melanocortinergic Pathways. |
| المؤلفون: |
Greenfield, Jerry R., Miller, Jeffrey W., Keogh, Julia M., Henning, Elana, Satterwhite, Julie H., Cameron, Gregory S., Astruc, Beatrice, Mayer, John P., Brage, Soren, See, Teik Choon, Lomas, David J., O'Rahilly, Stephen, Farooqi, I. Sadaf |
| المصدر: |
New England Journal of Medicine. 1/1/2009, Vol. 360 Issue 1, p44-52. 9p. 6 Color Photographs. |
| مصطلحات موضوعية: |
*MEDICAL research, *CATECHOLAMINES, *REGULATION of blood pressure, *OBESITY, *GENETIC mutation, *GENES |
| مستخلص: |
The article presents a study which assessed blood pressure, heart rate, and urinary catecholamines in overweight or obese subjects with a loss-of-function mutation in the MC4R gene and in equally overweight control subjects. Researchers found the prevalence of hypertension to be markedly lower in the MC4R-deficient subjects than in the control subjects. The genetic and pharmacologic studies showed that melanocortinergic signaling is associated with the control of human blood pressure through a mechanism which is insulin-independent. |
| قاعدة البيانات: |
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