A Randomized Trial of a Cervical Pessary to Prevent Preterm Singleton Birth
| العنوان: | A Randomized Trial of a Cervical Pessary to Prevent Preterm Singleton Birth |
|---|---|
| المؤلفون: | Aikaterini Zamprakou, Jesus Rodriguez Calvo, Argyro Syngelaki, Ricardo Palma-Dias, Kypros H. Nicolaides, Mauro Parra-Cordero, Liona C. Poon, Evdoxia Skyfta, Gemma Picciarelli, Nataša Tul |
| المصدر: | New England Journal of Medicine. 374:1044-1052 |
| بيانات النشر: | Massachusetts Medical Society, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Cervical pessary, Pessary, medicine.medical_specialty, Randomization, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, medicine, 030212 general & internal medicine, Cervix, Gynecology, 030219 obstetrics & reproductive medicine, Intention-to-treat analysis, Singleton, business.industry, Obstetrics, Obstetrics and Gynecology, Gestational age, Odds ratio, General Medicine, medicine.disease, medicine.anatomical_structure, Premature birth, Gestation, business |
| الوصف: | BackgroundPreterm birth is the leading cause of neonatal and infant death and of disability among survivors. It is unclear whether a pessary inserted around the cervix reduces the risk of preterm singleton birth. MethodsWe conducted a multicenter, randomized, controlled trial comparing pessary placement with expectant management (control) in girls and women who were pregnant with singletons (singleton pregnancies) and who had a cervical length of 25 mm or less at 20 weeks 0 days to 24 weeks 6 days of gestation. Participants in either group who had a cervical length of 15 mm or less, at randomization or at subsequent visits, received treatment with vaginal progesterone. The primary outcome was spontaneous delivery before 34 weeks of gestation. ResultsIn an intention-to-treat analysis, there was no significant difference between the pessary group (465 participants) and the control group (467 participants) in the rate of spontaneous delivery before 34 weeks (12.0% and 10.8%, respectively; odds ratio in the p... |
| تدمد: | 1533-4406 0028-4793 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62675a4bd913e7de830bc09048df2c06Test https://doi.org/10.1056/nejmoa1511014Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....62675a4bd913e7de830bc09048df2c06 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334406 00284793 |
|---|